PROTAC SMARCA2/4 degrader-7
PROTAC SMARCA2/4 degrader-7 is a PROTAC-based degrader that targets SMARCA2 and SMARCA4, with DC50 values both < 100 nM. PROTAC SMARCA2/4 degrader-7 can be used in cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: VHL ligand (HY-159547); Black: linker (HY-W006635)).
For research use only. We do not sell to patients.
- CAS No.: 2568277-89-2
- Formula: C51H61N11O5S
- Molecular Weight:940.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4-degrader-7 (I-439) (24 hours) potently degrades SMARCA2 in A549 cells with a DC50 < 100 nM and > 90% maximum degradation after 24-hour incubation[1].
PROTAC SMARCA2/4-degrader-7 (24 hours) potently degrades both SMARCA2 and SMARCA4 in MV4-11 cells, with a DC50 < 100 nM and > 90% maximum degradation for each protein after 24-hour incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568277-89-2
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Molecular Weight 940.17
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Formula C51H61N11O5S
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SMILES
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC([C@@H]2CC[C@@H](C3=CN=C(N4C5CN(C6=C(N)N=NC(C7=C(C=CC=C7)O)=C6)CC4CC5)N=C3)CC2)=O)=O)NC8(C9=CC=C(C%10=C(N=CS%10)C)C=C9)CC8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-7 Related Classifications
HY-159458 Related Classifications
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