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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
106 Results for "
src tyrosine kinase
" in MedChemExpress (MCE) Product Catalog:
Products (106)
106 Results for "src tyrosine kinase" in MCE Product Catalog:
46
46 Publications Verification
Synonyms: AZD0530
Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases .
46
46 Publications Verification
Synonyms: AZD0530 difumarate
Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .
25
Research Areas:
Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively .
25
19
19 Cited Publications
Synonyms: src kinase Inhibitor 1; src-l1
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.
13
7
4
4 Cited Publications
Target:
Research Areas:
XL228 is a multi-targeted tyrosine kinase inhibitor with IC50s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src and Lyn, respectively.
3
3 Cited Publications
Research Areas:
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
3
3 Cited Publications
Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole
Target:
Research Areas:
MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor, a broad-spectrum antiplatelet agent, and a PANoptosis inhibitor. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells .
1
1 Cited Publications
Synonyms: BMS-354825-d8
1
1 Cited Publications
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
1
1 Cited Publications
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers .
1
1 Cited Publications
Cat. No.: HY-P701321
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: src; tyrosine kinase Pp60c-src; Prev. src1; P60-src; C-src; Protooncogene src, Rous Sarcoma; ASV; tyrosine-Protein kinase src-1; V-src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; Pp60c-src; Proto-Oncogene tyrosine-Protein kinase src; THC6; src Proto-Oncogene, Non-Receptor tyrosine kinase; Proto-Oncogene C-src
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73269
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LCK; P56(LSTRA) Protein-tyrosine kinase; LCK Proto-Oncogene, src Family tyrosine kinase; tyrosine-Protein kinase; Lymphocyte Cell-Specific Protein-tyrosine kinase; Proto-Oncogene Lck; T Cell-Specific Protein-tyrosine kinase; Protein YT16; Leukocyte C-Term
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P73486
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: YES1; YES Proto-Oncogene 1; src Family tyrosine kinase; HsT441; C-Yes; Yes; V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1; tyrosine-Protein kinase Yes; Proto-Oncogene C-Yes; YES1 Proto-Oncogene; src Family tyrosine kinase; Proto-Oncogene tyrosine-Pro
Species:
Human
Source:
Sf9 insect cells
PD166326 is an orally active tyrosine kinase inhibitor with a IC50 of 8 nM against abl tyrosine kinase and a IC50 of 6 nM against src tyrosine kinase. PD166326 blocks Bcr/Abl kinase activity. PD166326 inhibits Bcr/Abl-dependent proliferation and cell cycle progression. PD166326 reduces peripheral blood granulocytosis, alleviates splenomegaly and prolongs survival in a mouse model of chronic myeloid leukemia. PD166326 can be used in research related to chronic myeloid leukemia .
Target:
Research Areas:
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively . PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor .
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
