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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

src tyrosine kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Src (49) Syk (2) 5-HT Receptor (2) Adrenergic Receptor (3) Apoptosis (9) Aurora Kinase (1) Autophagy (8) Bacterial (3) Bcr-Abl (12) c-Kit (1) c-Met/HGFR (2) CaMK (2) COX (1) DNA-PK (1) Drug Derivative (1) EGFR (9) Ephrin Receptor (3) ERK (1) FGFR (7) IGF-1R (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JAK (2) Mitosis (1) mTOR (1) NOD-like Receptor (NLR) (1) p38 MAPK (2) PANoptosis (1) PDGFR (10) Phosphodiesterase (PDE) (2) PI3K (1) PKA (1) PKC (1) Reference Standards (8) RET (1) STAT (2) TGF-β Receptor (1) VEGFR (9)
By Research Areas:	Cancer (42) Cardiovascular Disease (5) Endocrinology (5) Infection (4) Inflammation/Immunology (11) Neurological Disease (3)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Src SHP2 Btk Syk Pyk2 TNK1 Tyrosine Hydroxylase DYRK BRK FAK SHP1 FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10234

Saracatinib Maximum Cited Publications 39 Publications Verification AZD0530	Src Autophagy	Cancer
Saracatinib (AZD0530) is a potent *Src* family inhibitor with IC₅₀s of 2.7 to 11 nM for *c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine* kinases .

HY-10158

Bosutinib 20+ Cited Publications SKI-606	Src Bcr-Abl Autophagy	Cancer
Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC₅₀ of 1.2 nM and 1 nM, respectively .

HY-101053

Src Inhibitor 1 15+ Cited Publications src kinase Inhibitor 1; src-l1	Src	Cancer
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site *Src* tyrosine kinase inhibitor with IC₅₀ values of 44 nM for Src and 88nM for Lck.

HY-13804

PP1 10+ Cited Publications AGL 1872; EI 275	Src Apoptosis	Cancer
PP1 is a potent, and *Src* family-selective tyrosine kinase inhibitor with IC₅₀ of 5 and 6 nM for Lck and Fyn, respectively.

HY-16558

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-10158A

Bosutinib hydrate 20+ Cited Publications SKI-606 hydrate	Src Bcr-Abl	Cancer
Bosutinib hydrate is an oraly activel **Src/Abl tyrosine kinase inhibito with IC₅₀** of 1.2 nM and 1 nM, respectively .

HY-118144

PD166326	Src Bcr-Abl p38 MAPK	Cancer
PD166326 is an orally active **tyrosine kinase inhibitor with a IC₅₀ of 8 nM against abl** tyrosine kinase and a IC₅₀ of 6 nM against *src* tyrosine kinase. PD166326 blocks Bcr/Abl kinase activity. PD166326 inhibits Bcr/Abl-dependent proliferation and cell cycle progression. PD166326 reduces peripheral blood granulocytosis, alleviates splenomegaly and prolongs survival in a mouse model of chronic myeloid leukemia. PD166326 can be used in research related to chronic myeloid leukemia .

HY-10181S

Dasatinib-d8 1 Publications Verification BMS-354825-d₈	Bcr-Abl Src Apoptosis Autophagy	Cancer
Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-15749

XL228 4 Publications Verification	Aurora Kinase Bcr-Abl IGF-1R Src	Endocrinology Cancer
XL228 is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, *Src* and Lyn, respectively.

HY-18303

AMG-47a 3 Publications Verification	Src VEGFR p38 MAPK JAK	Inflammation/Immunology
AMG-47a is an orally active, ATP-competitive Lck inhibitor (IC₅₀=0.2 nM). AMG-47a inhibits VEGF2, p38α, p38α, Jak3, MLR, and IL-2 with IC₅₀ of 1 nM, 3 nM, 72 nM, 30 nM, and 21 nM, respectively. AMG-47a reduces T cell activation and the production of cytokines such as TGF-β, exerting anti-inflammatory and anti-fibrotic activities. AMG-47a can be used in the research of autoimmune diseases, pulmonary fibrosis, and KRAS mutation-associated cancers[1][2][3].

HY-100434

PD-161570	FGFR PDGFR EGFR Src TGF-β Receptor	Cardiovascular Disease Cancer
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC₅₀ of 39.9 nM and a K_i of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC₅₀ values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC₅₀s of 450 nM and 622 nM, respectively . PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor .

HY-10185

TG 100572 Hydrochloride 3 Publications Verification	Src VEGFR FGFR PDGFR	Inflammation/Immunology
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀*s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src*, Yes, respectively.

HY-78263

MNS 3 Publications Verification NSC 170724; 5-(2-Nitrovinyl)benzodioxole	Src Syk NOD-like Receptor (NLR) Integrin PANoptosis	Neurological Disease Inflammation/Immunology Cancer
MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active **tyrosine kinase inhibitor, a broad-spectrum antiplatelet agent, and a PANoptosis** inhibitor. MNS inhibits Src, Syk, and FAK with IC₅₀ of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC₅₀ values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells .

HY-10186

TG 100801 1 Publications Verification	VEGFR FGFR PDGFR Src	Cancer
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes**, respectively.

HY-N4201

β-Hydroxyisovalerylshikonin	EGFR Src	Cancer
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of *protein tyrosine* kinases (PTK), with IC₅₀*s of 0.7μM and 1μM for EGFR and v-Src* receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .

HY-103094

LY266097 hydrochloride	5-HT Receptor	Inflammation/Immunology
LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pK_is of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression .

HY-123450

S116836	Bcr-Abl Apoptosis PDGFR	Cancer
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149007

STAT3-IN-11 1 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers .

HY-13342AS

Apatinib-d8 free base YN968D1-d8 free base	Src VEGFR Autophagy c-Kit RET	Cancer
Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base . Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-10234A

Saracatinib difumarate Maximum Cited Publications 39 Publications Verification AZD0530 difumarate	Src	Cancer
Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .

HY-10184

TG 100572	Src VEGFR PDGFR FGFR	Cancer
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀*s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src*, Yes, respectively.

HY-N7160

2-Hydroxy-3-methylanthraquinone	Src Apoptosis	Cancer
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-112345

PD-089828	FGFR PDGFR EGFR Src	Cancer
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC₅₀s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of *c-Src* tyrosine kinase (IC₅₀=0.18 µM). PD-089828 also inhibits MAPK with an IC₅₀ of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity .

HY-112386

OXSI-2	Syk	Inflammation/Immunology
OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC₅₀ of 313 nM and an IC₅₀ of 14 nM .

HY-15268

PP487	c-Met/HGFR PI3K DNA-PK mTOR Bcr-Abl Src VEGFR EGFR PDGFR	Cancer
PP487 is a selective dual inhibitor of **Tyrosine kinase/PI3-K, with IC₅₀ values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR**, respectively. PP487 can be used in cancer research .

HY-W013857

Lavendustin C	CaMK EGFR Src	Cancer
Lavendustin C is a potent *Ca ²⁺ calmodulin-dependent kinase* II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR*-associated tyrosine* kinase (IC₅₀=0.012 µM) and pp60 ^c-src(+) kinase (IC₅₀=0.5 µM) .

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for **src-tyrosine-specific protein kinase** .

HY-P3773

p60c-src substrate II	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-P3743

p60c-src Substrate	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-10187

TG 100801 Hydrochloride	VEGFR FGFR PDGFR Src	Cancer
TG 100801 Hydrochloride is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀*s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src*, Yes, respectively.

HY-110367A

LCB 03-0110	Src	Others
LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation .

HY-110367

LCB 03-0110 dihydrochloride	Src	Others
LCB 03-0110 dihydrochloride is a dihydrochloride of LCB 03-0110. LCB 03-0110 is a potent inhibitor of **Src family tyrosine kinase** .

HY-B1308

Adrenalone hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC₅₀ of 36.9 μM .

HY-B1308A

Adrenalone	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone is an inhibitor of dopamine β oxidase. Adrenalone is chemically similar to known norepinephrine transporter (NET) ligands with an IC₅₀ of 36.9 μM .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-P2547A

Tyrosine Kinase Peptide 1 acetate	Src	Others
Tyrosine Kinase Peptide 1 (acetate) is a control substrate peptide for c-Src assay .

HY-P2547

Tyrosine Kinase Peptide 1	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-N14271

Hibarimicin B Angelmicin B	Src Bacterial	Infection Cancer
Hibarimicin B (Angelmicin B) is a tyrosine kinase inhibitor. It selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. It also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-P2372

P60v-src(137-157)	Src	Others
P60v-src(137-157) is a synthetic peptide that inhibits the tyrosine kinase activity of p60 ^v-src (IC₅₀: 7.5 μM) .

HY-N14273

Hibarimicin C	Src Bacterial	Infection Cancer
Hibarimicin C is a tyrosine kinase inhibitor. Hibarimicin C selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin C also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14689

Hibarimicin D	Src	Infection Cancer
Hibarimicin D is a tyrosine kinase inhibitor. Hibarimicin D selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin D also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14267

Hibarimicin A	Src Bacterial	Infection Cancer
Hibarimicin A is a tyrosine kinase inhibitor found in Microbispora rosea subsp. hibaria. Hibarimicin A selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin A also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-171218

CGP062464	Src	Cancer
CGP062464 is an inhibitor of the tyrosine kinase *c-Src* (IC₅₀: < 50 nM). CGP062464 can be used for research of osteoporosis and tumor-induced hypercalcemia .

HY-10234AR

Saracatinib difumarate (Standard) AZD0530 difumarate (Standard)	Src Reference Standards	Cancer
Saracatinib (difumarate) (Standard) is the analytical standard of Saracatinib (difumarate). This product is intended for research and analytical applications. Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .

HY-10234R

Saracatinib (Standard) AZD0530 (Standard)	Reference Standards Src Autophagy	Cancer
Saracatinib (Standard) is the analytical standard of Saracatinib. This product is intended for research and analytical applications. Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases .

HY-123506

Fenlean	Src	Neurological Disease Inflammation/Immunology
Fenlean, a natural squamosamide derivative, is a **Src tyrosine kinase** inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models .

HY-171217

TG-100435	Src Bcr-Abl Ephrin Receptor	Cancer
TG-100435 is a multitargeted, orally active protein **tyrosine kinase inhibitor, with K_i of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4**. TG-100435 plays an important role in cancer research .

HY-10158AR

Bosutinib hydrate (Standard) SKI-606 hydrate (Standard)	Reference Standards Src Bcr-Abl	Cancer
Bosutinib (Standard) (SKI-606 (Standard)) hydrate is the analytical standard of Bosutinib hydrate (HY-10158A). This product is intended for research and analytical applications. Bosutinib hydrate is an oraly activel **Src/Abl tyrosine kinase inhibito with IC₅₀**s of 1.2 nM and 1 nM, respectively.

HY-10158S1

Bosutinib-13C,d3 SKI-606-¹³C,d₃	Isotope-Labeled Compounds Autophagy Bcr-Abl Src	Cancer
Bosutinib- ¹³C,d₃ (SKI-606- ¹³C,d₃) is ¹³C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC₅₀ of 1.2 nM and 1 nM, respectively .

HY-108417

Debio 0617B	STAT JAK Bcr-Abl	Cancer
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 ⁺ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16558

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	Chalcones Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N4201

β-Hydroxyisovalerylshikonin	Quinones Classification of Application Fields Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer Source Classification	EGFR Src
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of *protein tyrosine* kinases (PTK), with IC₅₀*s of 0.7μM and 1μM for EGFR and v-Src* receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Anthraquinones Rubiaceae Plants Source Classification Hedyotis diffusa Willd.	Src Apoptosis
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N14271

Hibarimicin B Angelmicin B	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin B (Angelmicin B) is a tyrosine kinase inhibitor. It selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. It also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14273

Hibarimicin C	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin C is a tyrosine kinase inhibitor. Hibarimicin C selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin C also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14689

Hibarimicin D	Natural Products Microorganisms Source Classification	Src
Hibarimicin D is a tyrosine kinase inhibitor. Hibarimicin D selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin D also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14267

Hibarimicin A	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin A is a tyrosine kinase inhibitor found in Microbispora rosea subsp. hibaria. Hibarimicin A selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin A also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

Species:	Human (9) Mouse (4)
Tag:	His (8) Strep (1) Tag Free (3) Avi (1) GST (6) Flag (2)
Source:	sf9 insect cells (2) Sf9 insect cells (2) Sf9 insect cells (8) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73422

	Src Protein, Human (Active, sf9, His-GST) Proto-oncogene tyrosine-protein kinase src; src; p60-src; src1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P73423

	Src Protein, Mouse (Active, sf9, His-GST) Proto-oncogene tyrosine-protein kinase src; src; p60-src; src1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702724

	Src Protein, Human (Active, sf9, His, Flag) Proto-oncogene tyrosine-protein kinase src; src; p60-src; src1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells, with His, Flag labeled tag.

HY-P701321

	Src Protein, Human (Active, His) 1 Publications Verification Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src (p60-src); src1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag.

HY-P705885

	Src Protein, Human (Active, sf9) Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src (p60-src); src1	Human	sf9 insect cells

HY-P75322

	CSK Protein, Mouse (sf9) tyrosine-protein kinase CSK; C-src kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with tag free.

HY-P705884

	Src Protein, Human (Active, T341M, sf9, His-StrepII) Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src (p60-src); src1	Human	sf9 insect cells

HY-P72956

	CSK Protein, Human (Active, sf9, GST) tyrosine-protein kinase CSK; C-src kinase; CSK	Human	Sf9 insect cells
	CSK is a non-receptor tyrosine protein kinase that critically regulates cell growth, differentiation, migration and immune responses by phosphorylating tyrosine residues in the C-terminal tail of Src family kinases (SFK). This induces an inactive conformation through intramolecular interactions with the SH2 domain of SFK. CSK Protein, Human (Active, sf9, GST) is the recombinant human-derived CSK protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P72957

	CSK Protein, Mouse (Active, sf9, His-GST) tyrosine-protein kinase CSK; C-src kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72856

	Brk Protein, Mouse (Active, sf9, His-GST) Protein-tyrosine kinase 6; src-related intestinal kinase; Ptk6; Sik	Mouse	Sf9 insect cells
	Brk protein is a non-receptor tyrosine protein kinase that regulates signaling pathways critical for epithelial differentiation and tumor growth.Its context-dependent functions involve phosphorylating substrates such as RNA-binding proteins, transcription factors, and signaling molecules.Brk Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Brk protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75470

	Brk/PTK6 Protein, Human (sf9, GST) Protein-tyrosine kinase 6; src-related intestinal kinase; Ptk6; Sik	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk/PTK6 Protein, Human (sf9, GST) is the recombinant human-derived Brk protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P705567

	Lck Protein, Human (sf9) tyrosine-protein kinase Lck; Leukocyte C-terminal src kinase (LSK); Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	Human	Sf9 insect cells

HY-P702727

	FYN Protein, Human (Active, Biotinylated, sf9, His, Flag, Avi) FYN; FYN oncogene related to src, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regulator; p59-FYN	Human	Sf9 insect cells
	FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) is the recombinant human-derived FYN, expressed by Sf9 insect cells , with Avi, His, Flag labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-10181S

Dasatinib-d8 1 Publications Verification
Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base . Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-10158S1

Bosutinib-13C,d3
Bosutinib- ¹³C,d₃ (SKI-606- ¹³C,d₃) is ¹³C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC₅₀ of 1.2 nM and 1 nM, respectively .

Host:	Mouse (8) Rabbit (8)
Reactivity:	Human (14) Mouse (8) Rat (10) Monkey (2)
Application:	IHC-P (6) ICC/IF (9) IF-Tissue (1) IP (6) IHC-F (1) WB (16) FC (3) ELISA (6)
Isotype:	IgG (5) IgG1 (2) IgG/Kappa (3)
Conjugation:	Non-conjugated (16) Biotin (1)
Clonality:	Polyclonal (1) Monoclonal (13) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (12)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85546

	CSK Antibody (YA5238) C src; C src kinase; C src tyrosine kinase; C-src kinase; c-src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC tyrosine kinase; MGC112926; MGC117393; MGC154049; P60 src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL; Proto oncogene tyrosine protein kinase; tyrosine protein kinase CSK; tyrosine protein kinase CSK; tyrosine-protein kinase CSK; zgc:154049.	WB, ICC/IF	Human, Rat
	CSK Antibody (YA5238) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CSK.

HY-P82997

	CSK Antibody (YA2742) CSK; tyrosine-protein kinase CSK; C-src kinase; Protein-tyrosine kinase CYL	WB, IHC-P	Human, Mouse, Rat
	CSK Antibody (YA2742) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CSK.

HY-P85111

	CSK Antibody (YA4803) CSK; tyrosine-protein kinase CSK; C-src kinase; Protein-tyrosine kinase CYL	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	CSK Antibody (YA4803) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CSK.

HY-P86318

	Src Antibody (YA6010) Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src; p60-src;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Src Antibody (YA6010) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Src.

HY-P82911

	Phospho-Src (Tyr530) Antibody (YA2656) src; src1; Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src; p60-src	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src (Tyr530).

HY-P86105

	Phospho-Src Family(Tyr416) Antibody (YA5797) src; src1; Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src; p60-src; ASV;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Src Family(Tyr416) Antibody (YA5797) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src Family(Tyr416).

HY-P82911A

	Phospho-Src (Tyr530) Antibody (YA2656)(PBS only) src; src1; Proto-oncogene tyrosine-protein kinase src; Proto-oncogene c-src; pp60c-src; p60-src	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src (Tyr530).

HY-P85545

	Fyn Antibody (YA5237) C syn protooncogene; Fyn; FYN oncogene related to src FGR YES; FYN_HUMAN; MGC45350; OKT3 induced calcium influx regulator; P59 FYN; p59-Fyn; Protein tyrosine kinase fyn; Proto oncogene tyrosine protein kinase fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Protooncogene Syn; SLK; src like kinase; src yes related novel gene; src-like kinase; src/yes related novel; src/yes related novel gene; SYN; tyrosine kinase p59fyn T; tyrosine kinase p59fyn; T; tyrosine-protein kinase Fyn.	WB, ICC/IF	Human, Monkey, Rat, Mouse
	Fyn Antibody (YA5237) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fyn.

HY-P80743

	Lck Antibody (YA712) LCK; tyrosine-protein kinase Lck; Leukocyte C-terminal src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

HY-P86477

	Lck Antibody (YA6169) LCK; tyrosine-protein kinase Lck; Leukocyte C-terminal src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lck Antibody (YA6169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lck.

HY-P85255

	Lck Antibody (YA4947) LCK; tyrosine-protein kinase Lck; Leukocyte C-terminal src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human
	Lck Antibody (YA4947) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P80743A

	Lck Antibody (YA712)(PBS only) LCK; tyrosine-protein kinase Lck; Leukocyte C-terminal src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

HY-P80681

	Fyn Antibody FYN; tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; src-like kinase; SLK; p59-Fyn	WB	Human, Mouse, Rat
	Fyn Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Fyn.

HY-P85555

	Lck Antibody (YA5247) LCK; Lck p56; LCK_HUMAN; Leukocyte C-terminal src kinase; LSK; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte cell-specific protein-tyrosine kinase; Lymphocyte Specific Protein tyrosine kinase; Membrane associated protein tyrosine kinase; Oncogene lck; P56 LCK; p56; LSTRA; protein tyrosine kinase; p56-LCK; p56lck; pp58 lck; pp58lck; Protein YT16; Proto oncogene tyrosine protein kinase LCK; Proto-oncogene Lck; Protooncogene tyrosine protein kinase LCK; T cell specific protein tyrosine kinase; T cell-specific protein-tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56lck; tyrosine-protein kinase Lck; YT 16; YT16.	WB	Human
	Lck Antibody (YA5247) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P85176

	Fyn Antibody (YA4868) FYN; tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; src-like kinase; SLK; p59-Fyn	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Fyn Antibody (YA4868) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fyn.

HY-P85100

	FGR Antibody (YA4792) FGR; src2; tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr; oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	FGR Antibody (YA4792) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FGR.

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Cat. No.	Product Name		Classification

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

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