1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. CaMK
    EGFR
    Src
  3. Lavendustin C

Lavendustin C 

Cat. No.: HY-W013857
Handling Instructions

Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) .

For research use only. We do not sell to patients.

Lavendustin C Chemical Structure

Lavendustin C Chemical Structure

CAS No. : 125697-93-0

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Description

Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].

IC50 & Target[1][2]

CaMK II

0.2 μM (IC50)

EGFR

0.012 μM (IC50)

In Vitro

Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1].
Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3].

Molecular Weight

275.26

Formula

C₁₄H₁₃NO₅

CAS No.

125697-93-0

SMILES

O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lavendustin CCaMKEGFRSrcCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesEpidermal growth factor receptorErbB-1HER1Ca2+calmodulin-dependentkinaseIItyrosinepp60Inhibitorinhibitorinhibit

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Lavendustin C
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