125697-93-0
125697-93-0
Chemical Structure
Lavendustin C
- CAS No.: 125697-93-0
- Formula:C14H13NO5
- Molecular Weight:275.26
IUPAC Name: 5-((2,5-dihydroxybenzyl)amino)-2-hydroxybenzoic acid
InChIKey: LULATDWLDJOKCX-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O
Biological Activity: Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src(+) kinase (IC50=0.5 μM) [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Lavendustin C | 98.17% | Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src(+) kinase (IC50=0.5 μM) . | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7. [Content Brief]
- [2]. T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60. [Content Brief]
Keywords
