125697-93-0
125697-93-0
Chemical Structure
Lavendustin C
- CAS No.: 125697-93-0
- Formula:C14H13NO5
- Molecular Weight:275.26
IUPAC Name: 5-((2,5-dihydroxybenzyl)amino)-2-hydroxybenzoic acid
InChIKey: LULATDWLDJOKCX-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O
Biological Activity: Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src(+) kinase (IC50=0.5 μM) [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lavendustin C | 98.17% | Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src(+) kinase (IC50=0.5 μM) . | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-116138RG-14467 -
Similarity Score 0.77
HY-117718RAG957 (Standard) -
Similarity Score 0.71
HY-100456RZL006 (Standard) -
Similarity Score 0.71
HY-B0174AROlsalazine (Standard) -
Similarity Score 0.71
HY-W3452265,5'-Methylenebis(2-hydroxybenzoic acid) -
Similarity Score 0.70
![4,4'-Dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075387.gif)
HY-W0753874,4'-Dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid -
Similarity Score 0.69
HY-Z7686Mesalazine impurity 3 -
Similarity Score 0.69
HY-105005Crisdesalazine -
Similarity Score 0.67
![3,3'-Dihydroxy-[1,1'-biphenyl]-4,4'-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075947.gif)
HY-W0759473,3'-Dihydroxy-[1,1'-biphenyl]-4,4'-dicarboxylic acid -
Explore the MedChemAI to find more analogs
![4,4'-Dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075387.gif)
![3,3'-Dihydroxy-[1,1'-biphenyl]-4,4'-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075947.gif)
References
- [1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7. [Content Brief]
- [2]. T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60. [Content Brief]
