2. Protein Tyrosine Kinase/RTK Neuronal Signaling TGF-beta/Smad Stem Cell/Wnt JAK/STAT Signaling Epigenetics Immunology/Inflammation
  3. Src CaMK PKA EGFR PKC COX
  4. TX-1123

TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.

For research use only. We do not sell to patients.

TX-1123 Chemical Structure

TX-1123 Chemical Structure

CAS No. : 157397-06-3

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TX-1123 Related Antibodies

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Lck

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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COX COX-1 COX-2 COX-3

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Description

TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].

IC50 & Target[2]

COX-2

1.16 nM (IC50)

COX-1

15.7 μM (IC50)

In Vitro

TX-1123 (NIH3T3 cells) inhibits Src-K, eEF2-K, PKA, PKC, EGFR-k with IC50 values of 2.2, 3.2, 9.6, 320, and 320 μM, respectively[1].
TX-1123 (mitochondrial suspension) has a weaker mitochondrial toxicity and ATP-synthesis inhibitory activities with an IC50 value of 5 μM[1].
TX-1123 (0-1000 μM; 48 h) has antitumor activity with IC50 values of 3.66, 39, and 57 μM for HepG2, HCT116, and Rat hepatocytes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TX-1123 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, HCT116, and Rat hepatocytes
Concentration: 0-1000 μM
Incubation Time: 48 hours
Result: Inhibited tumor cell growth in a dose-dependent manner.
Molecular Weight

312.40

Formula

C20H24O3
CAS No.
SMILES

O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TX-1123 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX-1123157397-06-3TX1123TX 1123SrcCaMKPKAEGFRPKCCOXCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesProtein kinase AEpidermal growth factor receptorErbB-1HER1Protein kinase CCyclooxygenaseprotein tyrosine kinasecancerNIH3T3 cellsmitochondrialtoxicityInhibitorinhibitorinhibit

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