TX-1123
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
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- CAS No.: 157397-06-3
- Formule: C20H24O3
- Masse moléculaire:312.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[2]|
COX-2 1.16 nM (IC50) |
COX-1 15.7 μM (IC50) |
In Vitro
TX-1123 (NIH3T3 cells) inhibits Src-K, eEF2-K, PKA, PKC, EGFR-k with IC50 values of 2.2, 3.2, 9.6, 320, and 320 μM, respectively[1].
TX-1123 (mitochondrial suspension) has a weaker mitochondrial toxicity and ATP-synthesis inhibitory activities with an IC50 value of 5 μM[1].
TX-1123 (0-1000 μM; 48 h) has antitumor activity with IC50 values of 3.66, 39, and 57 μM for HepG2, HCT116, and Rat hepatocytes, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:HepG2, HCT116, and Rat hepatocytes
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Concentration:0-1000 μM
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Incubation Time:48 hours
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Result:Inhibited tumor cell growth in a dose-dependent manner.
Chemical Information
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CAS No. 157397-06-3
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Masse moléculaire 312.40
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Formule C20H24O3
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SMILES
O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hori H, et, al. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. [Content Brief]
[2]. Ohkura K, et, al. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs. Anticancer Res. 2017 Jul;37(7):3849-3854. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TX-1123 Related Classifications
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