157397-06-3
157397-06-3
Chemical Structure
TX-1123
- CAS 番号: 157397-06-3
- Formula:C20H24O3
- Molecular Weight:312.40
IUPAC Name: 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclopent-4-ene-1,3-dione
InChIKey: VUEUMQIBGLKJJD-UHFFFAOYSA-N
SMILES: O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Biological Activity: TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].
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TX-1123 | TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer. | |||||||||||||||||||||
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References
- [1]. Hori H, et, al. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. [Content Brief]
- [2]. Ohkura K, et, al. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs. Anticancer Res. 2017 Jul;37(7):3849-3854. [Content Brief]
