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Cat. No.: HY-171218

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CGP062464

CGP062464 is an inhibitor of the tyrosine kinase c-Src (IC₅₀: < 50 nM). CGP062464 can be used for research of osteoporosis and tumor-induced hypercalcemia.

For research use only. We do not sell to patients.

CAS No.: 121405-24-1
Formula: C₁₈H₁₄N₄
Molecular Weight:286.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CGP062464 Chemical Structure

CAS No.: 121405-24-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CGP062464 is an inhibitor of the tyrosine kinase c-Src (IC₅₀: < 50 nM). CGP062464 can be used for research of osteoporosis and tumor-induced hypercalcemia^[1].

All Src Isoforms :

Chemical Information

CAS No. 121405-24-1
Molecular Weight 286.33
Formula C₁₈H₁₄N₄
SMILES

NC1=NC=NC2=C1C(C3=CC=CC=C3)=CN2C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Missbach M, et al. Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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