Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src

  • Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. doi: 10.1016/s0960-894x(00)00131-1.
M Missbach  1 ,  E Altmann ,  L Widler ,  M Susa ,  E Buchdunger ,  H Mett ,  T Meyer ,  J Green
Affiliations
  • 1. Novartis Pharma AG, Therapeutic Areas Arthritis & Bone Metabolism, Basel, Switzerland. [email protected]
PMID: 10853665 DOI: 10.1016/s0960-894x(00)00131-1
Abstract

5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.

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