1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. LY266097 hydrochloride

LY266097 hydrochloride 

Cat. No.: HY-103094
Handling Instructions

LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.

For research use only. We do not sell to patients.

LY266097 hydrochloride Chemical Structure

LY266097 hydrochloride Chemical Structure

CAS No. : 172895-39-5

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Description

LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression[1].

IC50 & Target[1]

5-HT2B Receptor

9.8 (pKi)

5-HT2A Receptor

7.7 (pKi)

5-HT2C Receptor

7.6 (pKi)

In Vitro

LY266097 is a highly selective 5-HT2B receptor antagonist with a pKi of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity over human 5-HT2C and 5-HT2A sites[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) [1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 250-350 g[1]
Dosage: 0.6 mg/kg
Administration: Administered i.p. alone or concomitantly with Escitalopram (2 mg/kg) for 2 days
Result: Short-term administration (0.6 mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.
Molecular Weight

407.33

Formula

C21H24Cl2N2O2

CAS No.
SMILES

CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
LY266097 hydrochloride
Cat. No.:
HY-103094
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