PD-161570

Cat. No.: HY-100434 Purity: 99.04%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC₅₀ of 39.9 nM and a K_i of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC₅₀ values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC₅₀s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.

For research use only. We do not sell to patients.

PD-161570 Chemical Structure

CAS No. : 192705-80-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 316	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 316	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 128	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC₅₀ of 39.9 nM and a K_i of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC₅₀ values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC₅₀s of 450 nM and 622 nM, respectively^[1]^[2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor^[3].

In Vitro

PD-161570 (Compound 6c; 0.1-1 µM; 1-8 days; VSMCs) treatment inhibits PDGF-stimulated vascular smooth muscle cell proliferation in a dose dependent fashion with an IC₅₀ of 0.3 µM on day 8^[1].
PD-161570 suppresses constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A_121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A_121(p) cells in culture^[2].
PD-161570 can potently inhibit basic fibroblast growth factor (bFGF)-mediated angiogenesis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Vascular smooth muscles cells (VSMCs)
Concentration:	0.1 µM, 0.3 µM, 1 µM
Incubation Time:	1 day, 3 days, 6 days, 8 days
Result:	Inhibited VSMC proliferation in a dose dependent fashion with an IC₅₀ of 0.3 µM at day 8.

Molecular Weight

532.51

Formula

C₂₆H₃₅Cl₂N₇O

CAS No.

192705-80-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (62.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8779 mL	9.3895 mL	18.7790 mL
5 mM	0.3756 mL	1.8779 mL	3.7558 mL
10 mM	0.1878 mL	0.9389 mL	1.8779 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.04%

Select Batch:

Data Sheet (275 KB) SDS (420 KB)

COA (248 KB) HNMR (282 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8779 mL	9.3895 mL	18.7790 mL	46.9475 mL
	5 mM	0.3756 mL	1.8779 mL	3.7558 mL	9.3895 mL
	10 mM	0.1878 mL	0.9389 mL	1.8779 mL	4.6947 mL
	15 mM	0.1252 mL	0.6260 mL	1.2519 mL	3.1298 mL
	20 mM	0.0939 mL	0.4695 mL	0.9389 mL	2.3474 mL
	25 mM	0.0751 mL	0.3756 mL	0.7512 mL	1.8779 mL
	30 mM	0.0626 mL	0.3130 mL	0.6260 mL	1.5649 mL
	40 mM	0.0469 mL	0.2347 mL	0.4695 mL	1.1737 mL
	50 mM	0.0376 mL	0.1878 mL	0.3756 mL	0.9389 mL
	60 mM	0.0313 mL	0.1565 mL	0.3130 mL	0.7825 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-161570192705-80-9PD161570PD 161570Inhibitorinhibitorinhibit

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