1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    TGF-beta/Smad
  2. FGFR
    PDGFR
    EGFR
    Src
    TGF-β Receptor
  3. PD-161570

PD-161570 

Cat. No.: HY-100434
Handling Instructions

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.

For research use only. We do not sell to patients.

PD-161570 Chemical Structure

PD-161570 Chemical Structure

CAS No. : 192705-80-9

Size Price Stock
5 mg USD 245 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All FGFR Isoform Specific Products:

View All PDGFR Isoform Specific Products:

View All EGFR Isoform Specific Products:

View All TGF-β Receptor Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[1][2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor[3].

IC50 & Target[1][2][3]

FGFR1

39.9 nM (IC50)

FGFR1

42 nM (Ki)

FGFR1 autophosphorylation

622 nM (IC50)

PDGFRβ

262 nM (IC50)

PDGFR

310 nM (IC50)

EGFR

240 nM (IC50)

c-Src

44 nM (IC50)

TGF-β Receptor

 

In Vitro

PD-161570 (Compound 6c; 0.1-1 µM; 1-8 days; VSMCs) treatment inhibits PDGF-stimulated vascular smooth muscle cell proliferation in a dose dependent fashion with an IC50 of 0.3 µM on day 8[1].
PD-161570 suppresses constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture[2].
PD-161570 can potently inhibit basic fibroblast growth factor (bFGF)-mediated angiogenesis[4].

Cell Proliferation Assay[1]

Cell Line: Vascular smooth muscles cells (VSMCs)
Concentration: 0.1 µM, 0.3 µM, 1 µM
Incubation Time: 1 day, 3 days, 6 days, 8 days
Result: Inhibited VSMC proliferation in a dose dependent fashion with an IC50 of 0.3 µM at day 8.
Molecular Weight

532.51

Formula

C₂₆H₃₅Cl₂N₇O

CAS No.

192705-80-9

SMILES

O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PD-161570PD161570PD 161570FGFRPDGFREGFRSrcTGF-β ReceptorFibroblast growth factor receptorPlatelet-derived growth factor receptorEpidermal growth factor receptorErbB-1HER1Transforming growth factor beta receptorsFGFR1ATP-competitivetyrosinekinasesautophosphorylationanti-proliferationcardiovasculardiseaseangiogenesisanti-cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PD-161570
Cat. No.:
HY-100434
Quantity:
MCE Japan Authorized Agent: