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Bosutinib hydrate

(Synonyms: SKI-606 hydrate)
24 Cited Publications
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Based on 24 publication(s) in Google Scholar

Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 918639-08-4
  • Formula: C26H31Cl2N5O4
  • Molecular Weight:548.46
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Bosutinib hydrate Chemical Structure
    Bosutinib hydrate Chemical Structure
  • Experimental Validation Results for Bosutinib hydrate
  • Experimental Validation Results for Bosutinib hydrate
  • Experimental Validation Results for Bosutinib hydrate
  • Experimental Validation Results for Bosutinib hydrate
  • Experimental Validation Results for Bosutinib hydrate
CAS No.: 918639-08-4
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  • Bosutinib hydrate Chemical Structure
    Bosutinib hydrate Chemical Structure
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    Bosutinib hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     Bright-field microscopy images of 3D sphere cultures of MIA PaCa-2R and mKRC.1 with vehicles, MRTX849, dasatinib, DGY-06-116, and Bosutinib (0.1 μM) as well as combinations, after 7 days of treatment.

  • 1/16

    Bosutinib hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     The combined use of Bosutinib (0.1 μM), DGY-06-116, or Dasatinib with MRTX849 demonstrated a similar synergistic effect in mKRC.1 cells.

  • 1/16

    Bosutinib hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     Representative images of H&E staining of the liver, lung, pancreas, and spleen from mice bearing mKRC.1 tumors, treated with either vehicle or the combination of MRTX849 and Bosutinib.

  • 1/16

    Bosutinib hydrate purchased from MedChemExpress. Usage Cited in: Life Sci Alliance. 2022 Dec 20;6(3):e202201616. [Abstract]

    Customer Validation
     Primary neurons from embryo brains of of WT rats and Tspan7−/− rats at E17 were cultured for 6 d. The WT neurons were treated without or with 10 μM Bosutinib for 4 h. Then phosphorylated and total SRC, PSD95, SYN, GluR1, and GluR2 in the primary neurons were detected with Western blot.

  • 1/16

    Bosutinib hydrate purchased from MedChemExpress. Usage Cited in: Saudi J Biol Sci. 2022 Apr;29(4):2323-2328. [Abstract]

    Customer Validation
     K562 cells were incubated with Bosutinib (BOS) (250 nM) in the absence or addition of Boc-D-FMK (5 μM) for up to 48 h. Cell cycle phase distribution was assessed using flow cytometry, PI labeling of total DNA content, and the Guava Cell Cycle Assay software module. Left to right; colored areas indicate sub-G1, G0/G1, S and G2/M phases.

  • Bosutinib hydrate