1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Src
    Bcr-Abl
    Autophagy
  3. Bosutinib D8

Bosutinib D8 (Synonyms: SKI-606 D8)

Cat. No.: HY-10158S
Handling Instructions

Bosutinib D8 (SKI-606 D8) is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.

For research use only. We do not sell to patients.

Bosutinib D8 Chemical Structure

Bosutinib D8 Chemical Structure

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Description

Bosutinib D8 (SKI-606 D8) is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

IC50 & Target

IC50: 1.2 nM (Src), 1 nM (Abl)[1]

Molecular Weight

538.50

Formula

C₂₆H₂₁D₈Cl₂N₅O₃

SMILES

CN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bosutinib D8SKI-606 D8Bosutinib D 8Bosutinib D-8SrcBcr-AblAutophagyDeuteriumlabeleddualInhibitorinhibitorinhibit

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