380843-75-4
380843-75-4
Chemical Structure
Bosutinib
Synonym(s): SKI-606
- CAS 番号: 380843-75-4
- Formula:C26H29Cl2N5O3
- Molecular Weight:530.45
IUPAC Name: 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
InChIKey: UBPYILGKFZZVDX-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC
Biological Activity: Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Bosutinib | 99.97% | Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively. | ||||||||||||||||||||
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Bosutinib-13C,d3 | Bosutinib-13C,d3 (SKI-606-13C,d3) is 13C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively. | |||||||||||||||||||||
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Bosutinib-d8 | Bosutinib-d8 is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-10158ABosutinib hydrate -
Similarity Score 0.90
HY-171167Bosutinib analog-1 -
Similarity Score 0.88
HY-W770773Bosutinib N-Oxide -
Similarity Score 0.85
HY-103029Bosutinib isomer -
Similarity Score 0.85
HY-175681CaMKIIα ligand-1 -
Similarity Score 0.78
HY-10188SKS-927 -
Similarity Score 0.59
HY-116184PF-05387252 -
Similarity Score 0.56
HY-168305EGFR ligand-11 -
Similarity Score 0.55
HY-W561311M387783 -
Explore the MedChemAI to find more analogs
