2. Cell Cycle/DNA Damage Epigenetics
  3. CDK DNA/RNA Synthesis Histone Demethylase Histone Methyltransferase
  4. Ryuvidine

Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM. Ryuvidine also inhibits KDM5A and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis.

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Ryuvidine

Ryuvidine 構造式

CAS 番号 : 265312-55-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 在庫あり
Solution
10 mM * 1 mL in DMSO USD 198 在庫あり
Solid
1 mg $80 在庫あり
5 mg $180 在庫あり
10 mg $265 在庫あり
25 mg $448 在庫あり
50 mg $672 在庫あり
100 mg $940 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Ryuvidine 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Histone Demethylase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Histone Methyltransferase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM. Ryuvidine also inhibits KDM5A and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis[1][2][3][4][5].

IC50 & Target

CDK4

6.0 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.61 mg/mL
Compound: K00601a, Benzothiazole1
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
[PMID: 18077363]
A549 IC50
0.61 μg/mL
Compound: 5g
Inhibition of A549 cancer cell proliferation
Inhibition of A549 cancer cell proliferation
[PMID: 10743948]
COLO1 IC50
1.08 μg/mL
Compound: 5g
Inhibition of Col1 cancer cell proliferation
Inhibition of Col1 cancer cell proliferation
[PMID: 10743948]
HL-60 IC50
0.3 mg/mL
Compound: K00601a, Benzothiazole1
Antitumor activity in human HL60 cells
Antitumor activity in human HL60 cells
[PMID: 18077363]
HL-60 IC50
0.3 μg/mL
Compound: 5g
Inhibition of HL60 cancer cell proliferation
Inhibition of HL60 cancer cell proliferation
[PMID: 10743948]
HeLa IC50
0.37 μM
Compound: Ryuvidine
Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hr
Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hr
[PMID: 35525212]
HepG2 IC50
1.21 mg/mL
Compound: K00601a, Benzothiazole1
Antitumor activity against human HepG2 cells
Antitumor activity against human HepG2 cells
[PMID: 18077363]
HepG2 IC50
1.21 μg/mL
Compound: 5g
Inhibition of HepG2 cancer cell proliferation
Inhibition of HepG2 cancer cell proliferation
[PMID: 10743948]
HepG2 IC50
1.2 μg/mL
Compound: 4d
In vitro cytotoxicity against HepG2 cells (Hepatocarcinoma from ATCC) by MTT assay
In vitro cytotoxicity against HepG2 cells (Hepatocarcinoma from ATCC) by MTT assay
[PMID: 10915058]
Sf9 IC50
9.5 μM
Compound: Ryuvidine
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
> 20 μM
Compound: Ryuvidine
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
> 20 μM
Compound: Ryuvidine
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
> 20 μM
Compound: Ryuvidine
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
> 20 μM
Compound: Ryuvidine
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
> 20 μM
Compound: Ryuvidine
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
体外実験

Ryuvidine (1-20 µM, 1-9 h) reduces CDC7 levels and blocks DNA synthesis in HeLa cells[3].
Ryuvidine (48 h) strongly inhibits KAIMRC2 (a breast cancer cell line) cell growth at an IC50 value of 0.8 µM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ryuvidine 関連抗体

Western Blot Analysis[3]

Cell Line: HeLa cells
Concentration: 1, 5, 10, 20 µM
Incubation Time: 1, 3, 6, 9
Result: Decreased pSer40/41 MCM2 and CDC7 protein levels.
Did not obviously affect the adjacent CDC7-independent phosphorylation of Ser41.
Completely dephosphorylated MCM2 at 20 µM.
体内実験

Ryuvidine ameliorates arthritis pathogenesis in arthritis model mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

284.33

分子式

C15H12N2O2S
CAS 番号
Appearance

Solid

Color

Brown to black

SMILES

O=C1C=C(C(C2=C1SC(C)=N2)=O)NC3=CC=C(C)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 12.5 mg/mL (43.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5170 mL 17.5852 mL 35.1704 mL
5 mM 0.7034 mL 3.5170 mL 7.0341 mL
10 mM 0.3517 mL 1.7585 mL 3.5170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5170 mL 17.5852 mL 35.1704 mL 87.9260 mL
5 mM 0.7034 mL 3.5170 mL 7.0341 mL 17.5852 mL
10 mM 0.3517 mL 1.7585 mL 3.5170 mL 8.7926 mL
15 mM 0.2345 mL 1.1723 mL 2.3447 mL 5.8617 mL
20 mM 0.1759 mL 0.8793 mL 1.7585 mL 4.3963 mL
25 mM 0.1407 mL 0.7034 mL 1.4068 mL 3.5170 mL
30 mM 0.1172 mL 0.5862 mL 1.1723 mL 2.9309 mL
40 mM 0.0879 mL 0.4396 mL 0.8793 mL 2.1982 mL
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Ryuvidine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ryuvidine265312-55-8CDKDNA/RNA SynthesisHistone DemethylaseHistone MethyltransferaseCyclin dependent kinaseanticancerarthritisKAIMRC2HeLaInhibitorinhibitorinhibit

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製品名:
Ryuvidine
製品番号:
HY-100624
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