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Results for "

Herpes+simplex+virus

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) Akt (1) AMPK (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (6) Apoptosis (6) Autophagy (1) Bacterial (9) Caspase (1) CD3 (1) CMV (3) COX (1) Cyclic GMP-AMP Synthase (1) DNA/RNA Synthesis (17) Drug Derivative (2) DYRK (1) EBV (1) Enterovirus (1) Environmental Pollutants (3) FASTK (1) Fungal (1) GABA Receptor (1) GSK-3 (1) Histone Demethylase (1) HIV (3) HPV (2) HSP (1) HSV (57) IFNAR (1) Influenza Virus (4) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (3) mRNA (1) NF-κB (5) NO Synthase (1) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (3) Orthopoxvirus (6) p38 MAPK (1) PAK (1) Parasite (1) Reactive Oxygen Species (ROS) (3) Reference Standards (9) RSV (1) SARS-CoV (3) STAT (4) STING (3) Tau Protein (1) Thymidylate Synthase (1) TNF Receptor (1) VEGFR (2) Virus Protease (3) VZV (4)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Infection (73) Inflammation/Immunology (18) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	Nucleoside Analogs (1) Phospholipids (1) mRNA (1) Antisense Oligonucleotides (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6733

Aphidicolin Maximum Cited Publications 15 Publications Verification	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-14532

Brincidofovir 5 Publications Verification CMX001; HDP-CDV	CMV HSV Orthopoxvirus	Infection
Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .

HY-15303

Pritelivir 5+ Cited Publications AIC316; BAY 57-1293	DNA/RNA Synthesis HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-12725

ML324 5+ Cited Publications	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC₅₀ of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

HY-125474

Carrageenan 1 Publications Verification	Environmental Pollutants HIV HSV	Infection Cancer
Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice .

HY-168034

diABZI-4	STING Integrin NF-κB SARS-CoV	Infection Inflammation/Immunology
diABZI-4 is a STING activator and broad-spectrum antiviral agent with immunostimulatory activity. diABZI-4 triggers the TBK1-IRF3 and NF-κB signaling cascades by inducing STING oligomerization, thereby promoting the production of type I/III interferons and various proinflammatory cytokines. diABZI-4 exhibits broad-spectrum antiviral activity and effectively inhibits the replication of influenza A virus, SARS-CoV-2, herpes simplex virus, and other viruses. diABZI-4 also activates lymphocytes and macrophages to provide significant pre- and post-exposure protection in viral disease models. diABZI-4 can be used to study COVID-19, respiratory viral infections, and related immunopathological mechanisms .

HY-B1011

Edoxudine EUDR	Virus Protease	Infection
Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus .

HY-B0222

1-Docosanol 3 Publications Verification Behenyl alcohol	Environmental Pollutants HSV	Infection
1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV) .

HY-113431

Arabinosylhypoxanthine	Nucleoside Antimetabolite/Analog HSV DNA/RNA Synthesis	Infection
Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection .

HY-N2004

Isoborneol 1 Publications Verification (±)-Isoborneol	Environmental Pollutants HSV	Infection Neurological Disease
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) .

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-N0772

Isomangiferin 4 Publications Verification	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative	Infection Metabolic Disease Inflammation/Immunology Cancer
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-160222

HSV-60mer sodium	HSV STING IFNAR NF-κB	Infection
HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection .

HY-N6666

Vidarabine monohydrate 5+ Cited Publications	HSV Antibiotic	Infection
Vidarabine monohydrate is an adenine arabinoside. Vidarabine monohydrate an antiviral agent which is active against herpes simplex viruses (HSV) and varicella zoster viruses .

HY-P1958

Histone H4 (2-21)	HSV	Infection
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes .

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-N1060

Yatein	HSV Apoptosis	Infection Cancer
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity . Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression .

HY-W012738

DL-Pyroglutamic acid 1 Publications Verification	Influenza Virus GABA Receptor	Infection
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-N12717

Casuarinin	PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis	Infection Inflammation/Immunology Cancer
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of *Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus* infections .

HY-15303A

Pritelivir mesylate 5+ Cited Publications AIC316 mesylate; BAY 57-1293 mesylate	DNA/RNA Synthesis HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-106892

BW 348U87 348U87	DNA/RNA Synthesis	Infection
BW 348U87 is an inhibitor for ribonucleotide reductase, which exhibits synergistic effect with Acyclovir (HY-17422), potentiate the antiviral activity of Acyclovir against herpes simplex virus (HSV) in athymic nude mouse model .

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice . Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection .

HY-W002008

5-Nitrobarbituric acid	HSV	Infection Inflammation/Immunology
5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) .

HY-114247

FMAU D-FMAU	Nucleoside Antimetabolite/Analog	Infection Cancer
FMAU is a nucleoside analog and cell proliferation marker that can be phosphorylated by human thymidine kinase and subsequently incorporated into DNA. FMAU is applicable to research related to herpes simplex virus infection, various cancers, hepatitis B virus infection, and Epstein-Barr virus infection .

HY-14743B

Golotimod hydrochloride SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-15303B

Pritelivir mesylate hydrate 5+ Cited Publications AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	DNA/RNA Synthesis HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-17422B

Acyclovir monophosphate	DNA/RNA Synthesis HSV Antibiotic	Infection Cancer
Acyclovir monophosphate is a potent *anti-herpes simplex virus* (HSV)** agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-14532S

Brincidofovir-d6 CMX001-d₆; HDP-CDV-d₆	Isotope-Labeled Compounds HSV CMV Orthopoxvirus	Infection
Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-U00124

Tromantadine	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-15303AR

Pritelivir mesylate (Standard) AIC316 mesylate (Standard); BAY 57-1293 mesylate (Standard)	HSV Reference Standards	Infection
Pritelivir (mesylate) (Standard) is the analytical standard of Pritelivir (mesylate). This product is intended for research and analytical applications. Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2 .

HY-15303R

Pritelivir (Standard) AIC316 (Standard); BAY 57-1293 (Standard)	HSV Reference Standards	Infection
Pritelivir (Standard) is the analytical standard of Pritelivir. This product is intended for research and analytical applications. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2 .

HY-123211

WAY-150138	HSV	Infection
WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled

HY-U00224

BRL44385	EBV VZV HSV	Infection
BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

HY-177638

ISIS 1082	HSV	Infection
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-107338

Denotivir Vratizolin; Wratizolin	VZV HSV Interleukin Related	Infection Inflammation/Immunology Cancer
Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy .

HY-A0061S

Trifluridine-13C,15N2 Trifluorothymidine-¹³C,¹⁵N₂; 5-Trifluorothymidine-¹³C,¹⁵N₂; TFT-¹³C,¹⁵N₂	Thymidylate Synthase Nucleoside Antimetabolite/Analog HSV Orthopoxvirus	Cancer
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-149267

STING agonist-30	STING SARS-CoV	Infection
STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .

HY-174252

HSV-1/HSV-2-IN-3	DNA/RNA Synthesis HSV	Infection
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC₅₀ of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC₅₀ of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC₅₀ ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research .

HY-107801R

Inosine pranobex (Standard) Imunovir (Standard); Delimmun (Standard); Groprinosin (Standard); (Standard)	Reference Standards Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex (Standard) is the analytical standard of Inosine pranobex. This product is intended for research and analytical applications. Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-N6733R

Aphidicolin (Standard)	Reference Standards DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Aphidicolin (Standard) is the analytical standard of Aphidicolin. This product is intended for research and analytical applications. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-P5644

Retrocyclin-3	Bacterial	Infection
Retrocyclin-3 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P5643

Retrocyclin-2	Bacterial	Infection
Retrocyclin-2 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-N14563

Cycloviracin B1	Bacterial HSV	Infection
Cycloviracin B1 has anti-herpes simplex virus Type I (HSV-1) activity and has weak anti-Gram-positive bacterial activity .

HY-15303S

Pritelivir-d4-1 AIC316-d4-1; BAY 57-1293-d4-1	Isotope-Labeled Compounds HSV DNA/RNA Synthesis	Infection
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-N14564

Cycloviracin B2	Antibiotic HSV	Infection
Cycloviracin B2 is an antibiotic with antiviral activity. Cycloviracin B2 has a strong inhibitory activity against herpes simplex virus type 1 (HSV-1) .

HY-N14265

Kistamicin B	Influenza Virus	Infection
Kistamicin B has antiviral effect, and its ID₅₀s against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 μg/mL and 30 μg/mL .

HY-N12191

Cangorinine E-1	HSV	Others
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

Cat. No.	Product Name

HY-L113

Antiviral Traditional Chinese Medicine Active Compound Library

235 compounds

Increasing research have shown that Traditional Chinese Medicine (TCM) possess antiviral activities against various viral strains, such as herpes simplex virus, influenza virus, hepatitis B and C viruses, and SARS-CoV. To date, dozens of Chinese herbs and hundreds of natural TCM ingredients have been reported to exhibit good antiviral activities. Active components from TCM are one of the important sources for antiviral drugs discovery.

MCE designs a unique collection of 235 active compounds of antiviral Chinese Herbal Medicines. MCE Antiviral Traditional Chinese Medicine Active Compound Library is a useful tool for discovery antiviral drugs from TCM.

Cat. No.	Product Name	Type

HY-125474

Carrageenan

1 Publications Verification

Biochemical Assay Reagents

Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice .

Cat. No.	Product Name	Target	Research Area

HY-P1958

Histone H4 (2-21)	HSV	Infection
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice . Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection .

HY-P10153

gH625	Peptides	Others
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-P5644

Retrocyclin-3	Bacterial	Infection
Retrocyclin-3 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P5643

Retrocyclin-2	Bacterial	Infection
Retrocyclin-2 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-P1862

HSV-gB2 (498-505)	HSV	Infection
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope .

HY-14743R

Golotimod (Standard) SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)	Bacterial STAT Reference Standards	Infection Inflammation/Immunology Cancer
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99147

Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)	CD3	Infection Inflammation/Immunology
Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) is an Armenian Hamster-derived IgG antibody inhibitor, targeting to mouse TCR V gamma 2. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can deplete γδ T cell. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can be used for the researches of infection and immunology, such as herpes simplex virus-1 (HSV-1) infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6733

Aphidicolin Maximum Cited Publications 15 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Terpenoids Diterpenoids Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-B0222

1-Docosanol 3 Publications Verification Behenyl alcohol	Infection Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification	Environmental Pollutants HSV
1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV) .

HY-N2004

Isoborneol 1 Publications Verification (±)-Isoborneol	Structural Classification Other Monoterpenes Terpenoids Curcuma aromatica Salisb. cv. Wenyujin Plants Source Classification Zingiberaceae	Environmental Pollutants HSV
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) .

HY-N0772

Isomangiferin 4 Publications Verification	Infection Structural Classification Liliaceae Xanthones Classification of Application Fields Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Source Classification	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

HY-N1060

Yatein	Infection Cupressaceae Classification of Application Fields Chamaecyparis obtusa (Siebold & Zucc.) Endl. Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	HSV Apoptosis
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity . Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression .

HY-N12717

Casuarinin	Terminalia arjuna (Roxb. ex DC.) Wight & Arn. Structural Classification Combretaceae Phenols Polyphenols Plants Source Classification	PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of *Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus* infections .

HY-N6733R

Aphidicolin (Standard)	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Reference Standards DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus
Aphidicolin (Standard) is the analytical standard of Aphidicolin. This product is intended for research and analytical applications. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-N14563

Cycloviracin B1	Natural Products Microorganisms Source Classification	Bacterial HSV
Cycloviracin B1 has anti-herpes simplex virus Type I (HSV-1) activity and has weak anti-Gram-positive bacterial activity .

HY-N14564

Cycloviracin B2	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic HSV
Cycloviracin B2 is an antibiotic with antiviral activity. Cycloviracin B2 has a strong inhibitory activity against herpes simplex virus type 1 (HSV-1) .

HY-N14265

Kistamicin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Influenza Virus
Kistamicin B has antiviral effect, and its ID₅₀s against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 μg/mL and 30 μg/mL .

HY-N12191

Cangorinine E-1	Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Source Classification	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-N14446

Karalicin	Natural Products Microorganisms Source Classification	HSV
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-N14264

Kistamicin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Influenza Virus Bacterial
Kistamicin A has antiviral effect, and its ID₅₀s against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 μg/mL and 44 μg/mL. Kistamicin A also has anti-Gram-positive bacterial effects .

HY-B0222R

1-Docosanol (Standard) Behenyl alcohol (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards HSV
1-Docosanol (Standard) is the analytical standard of 1-Docosanol. This product is intended for research and analytical applications. 1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV) .

HY-N2004R

Isoborneol (Standard) (±)-Isoborneol (Standard)	Structural Classification Natural Products Curcuma aromatica Salisb. cv. Wenyujin Plants Source Classification Zingiberaceae	Reference Standards HSV
Isoborneol (Standard) is the analytical standard of Isoborneol. This product is intended for research and analytical applications. Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) .

HY-N0772R

Isomangiferin (Standard)	Structural Classification Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Source Classification	Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.

Cat. No.	Product Name	Chemical Structure

HY-14532S

Brincidofovir-d6

Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-W705873

Edoxudine-d5
Edoxudine-d₅ (EUDR-d₅) is the deuterium labeled Edoxudine (HY-B1011). Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus .

Cat. No.	Product Name		Classification

HY-14532

Brincidofovir 5 Publications Verification CMX001; HDP-CDV		Phospholipids
Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .

HY-113431

Arabinosylhypoxanthine		Nucleoside Analogs
Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection .

HY-177638

ISIS 1082		Antisense Oligonucleotides
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-177638A

ISIS 1082 sodium		Antisense Oligonucleotides
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-174517

Human TNFRSF14 mRNA		mRNA
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

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