HSV-1/HSV-2-IN-3
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research.
For research use only. We do not sell to patients.
- CAS No.: 3016396-78-1
- Formula: C24H22FN3O3S
- Molecular Weight:451.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Helicase |
Chemical Information
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CAS No. 3016396-78-1
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Molecular Weight 451.51
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Formula C24H22FN3O3S
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SMILES
O=C(N1[C@H](C)CC2=C1C=C(S(=O)(N)=O)C(F)=C2)[C@@H](C3)CC(C3=C4)=CC=C4C5=NC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HSV-1/HSV-2-IN-3 Related Classifications
HY-174252 Related Classifications
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