2. Anti-infection Neuronal Signaling PI3K/Akt/mTOR Stem Cell/Wnt
  3. HSV Tau Protein Akt GSK-3
  4. PAV-174

PAV-174 is a potent antiviral agent that targets a host protein. PAV-174 prevents Herpes simplex virus (HSV-1) infection in cells (IC50 of 0.02 μM in Vero cells) and human brain organoids. PAV-174 inhibits oxidized macrophage migration inhibitory factor (oxMIF)-induced tau phosphorylation in vitro and in vivo independent of infection. PAV-174 reduces HSV-1-induced tau phosphorylation via the Akt/GSK3β signaling pathway. PAV-174 can be used for Alzheimer’s disease research.

For research use only. We do not sell to patients.

PAV-174

PAV-174 Chemical Structure

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PAV-174 Related Antibodies

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HSV-1 HSV-2 HSV

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Akt Akt1 Akt2 Akt3

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GSK-3 GSK-3α GSK-3β

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Description

PAV-174 is a potent antiviral agent that targets a host protein. PAV-174 prevents Herpes simplex virus (HSV-1) infection in cells (IC50 of 0.02 μM in Vero cells) and human brain organoids. PAV-174 inhibits oxidized macrophage migration inhibitory factor (oxMIF)-induced tau phosphorylation in vitro and in vivo independent of infection. PAV-174 reduces HSV-1-induced tau phosphorylation via the Akt/GSK3β signaling pathway. PAV-174 can be used for Alzheimer’s disease research[1].

IC50 & Target[1]

HSV-1

0.02 μM (IC50)

GSK3β

 

Molecular Weight

505.46

Formula

C23H28IN3S
SMILES

CC1=C(N=C23)C([S+]=C3C=C(N4CCCC4)C=C2CC)=CC(N5CCCC5)=C1.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAV-174 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAV-174PAV174PAV 174HSVTau ProteinAktGSK-3Herpes simplex virusPKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3organoidsVero cellsHSV-1oxidized macrophage migration inhibitory factorAkt/GSK3β signaling pathwayAlzheimer’s diseaseInhibitorinhibitorinhibit

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