Antiviral agent 58
Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2.
For research use only. We do not sell to patients.
- CAS No.: 939655-35-3
- Formula: C24H18ClN3O
- Molecular Weight:399.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antiviral agent 58 (Compound J1) (6.25-200 μM; 48 h) exhibites a low cytotoxic effect on MDCK, A549, Vero and HRT18 cells at concentrations up to 200 μM[1].
Antiviral agent 58 can inhibit the infection of IAV strains such as H1N1, H7N9, H5N1, and H3N2, as well as oseltamivir (HY-13317)-resistant strains, with IC50 values ranging from 7.81 to 15.65 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IAV lung injury BALB/c mouse model[1].
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Dosage:15 mg/kg; 30 mg/kg; 60 mg/kg
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Administration:Oral, once daily for 5 days
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Result:Increased the survival rate of virus-infected mice, and decreased viral titer, lung index and lung inflammation damage.
Chemical Information
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CAS No. 939655-35-3
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Molecular Weight 399.87
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Formula C24H18ClN3O
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SMILES
O=C1NC2=C(C(C3=CC=C(Cl)C=C3)=NN2C4=CC=CC=C4)C(C5=CC=CC=C5)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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