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Results for "

Indole alkaloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (1) Akt (5) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Apoptosis (12) Atg8/LC3 (1) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (3) Calcium Channel (1) Cannabinoid Receptor (1) CDK (1) Cholinesterase (ChE) (1) COX (3) Dengue Virus (1) Drug Derivative (10) Drug Intermediate (1) EGFR (1) Endogenous Metabolite (4) Flavivirus (1) Free Fatty Acid Receptor (2) Fungal (4) Heme Oxygenase (HO) (1) HIV (1) HSP (1) Interleukin Related (4) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Leukotriene Receptor (2) METTL3 (1) Microtubule/Tubulin (1) mTOR (3) MyD88 (1) nAChR (1) Necroptosis (1) NF-κB (6) NO Synthase (3) Opioid Receptor (1) P-glycoprotein (1) p38 MAPK (1) Parasite (3) Phosphodiesterase (PDE) (1) PI3K (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (2) Ras (1) Reactive Oxygen Species (ROS) (4) Reference Standards (4) TNF Receptor (4) Toll-like Receptor (TLR) (1) Topoisomerase (3) TREM receptor (1) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (7) Endocrinology (1) Infection (12) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (18)

By Targets:

5-HT Receptor (3)

Adrenergic Receptor (1)

Akt (5)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

Apoptosis (12)

Atg8/LC3 (1)

Autophagy (1)

Bacterial (2)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Cannabinoid Receptor (1)

CDK (1)

Cholinesterase (ChE) (1)

COX (3)

Dengue Virus (1)

Drug Derivative (10)

Drug Intermediate (1)

EGFR (1)

Endogenous Metabolite (4)

Flavivirus (1)

Free Fatty Acid Receptor (2)

Fungal (4)

Heme Oxygenase (HO) (1)

HIV (1)

HSP (1)

Interleukin Related (4)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (1)

Leukotriene Receptor (2)

METTL3 (1)

Microtubule/Tubulin (1)

mTOR (3)

MyD88 (1)

nAChR (1)

Necroptosis (1)

NF-κB (6)

NO Synthase (3)

Opioid Receptor (1)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (3)

Phosphodiesterase (PDE) (1)

PI3K (2)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (2)

Ras (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (4)

TNF Receptor (4)

Toll-like Receptor (TLR) (1)

Topoisomerase (3)

TREM receptor (1)

Tyrosinase (1)

VEGFR (1)

By Research Areas:

Cancer (31)

Cardiovascular Disease (7)

Endocrinology (1)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (8)

Neurological Disease (18)

102

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0117

Indirubin Maximum Cited Publications 12 Publications Verification Couroupitine B; Indigo red; Indigopurpurin	Apoptosis	Cancer
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N6778

Paxilline 5+ Cited Publications	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)	Neurological Disease
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-N1163

Tetrahydroalstonine (-)-Tetrahydroalstonine	Adrenergic Receptor Atg8/LC3 Akt mTOR	Neurological Disease Endocrinology
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury .

HY-N2193

Hirsutine 1 Publications Verification	Flavivirus Dengue Virus Apoptosis	Infection Cancer
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .

HY-N6607

Tryptanthrin 5+ Cited Publications	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N3536

Canthin-6-one	Bacterial NO Synthase COX Akt NF-κB	Infection Inflammation/Immunology
Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities .

HY-W014971

Tryptamine hydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-B1021

Vincamine 1 Publications Verification	Free Fatty Acid Receptor	Cardiovascular Disease Metabolic Disease
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Topoisomerase	Cancer
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N11478

Villocarine A	Others	Metabolic Disease
Villocarine A is a natural vasorelaxant indole alkaloid .

HY-N0117A

(Z)-Indirubin (Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin	Apoptosis	Cancer
(Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N2197

Hirsuteine 2 Publications Verification	nAChR	Neurological Disease
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .

HY-N6776

Penitrem A	Potassium Channel	Neurological Disease Cancer
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .

HY-N10379

19-epi-Scholaricine	Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related	Inflammation/Immunology
19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .

HY-N6932

Voacamine	Cannabinoid Receptor P-glycoprotein PI3K Akt mTOR Apoptosis Autophagy EGFR	Metabolic Disease Cancer
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .

HY-121002

Alstonine	Parasite	Infection Neurological Disease Cancer
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Others	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-A0220

Rescinnamine 1 Publications Verification Reserpinine	Drug Derivative	Cardiovascular Disease Metabolic Disease
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .

HY-N10149

Nauclefine	Phosphodiesterase (PDE) Apoptosis	Cancer
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway .

HY-N6607R

Tryptanthrin (Standard)	Reference Standards Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N11665

Donasine	Others	Infection
Donasine, indole alkaloid, is a nature product with effect of reducing fever. Donasine can be isolated from the rhizomes of Arundo donax L .

HY-N16411

Carneamide A	Others	Others
Carneamide A is a prenylated indole alkaloid produced by a marine-derived Aspergillus sp .

HY-N16573

19-epi-Voacristine	Others	Cancer
19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .

HY-N9164

Hecubine	TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .

HY-N11479

Vallesiachotamine	Apoptosis Necroptosis	Cancer
Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity .

HY-W001288

Indole-4-carboxaldehyde	NF-κB	Metabolic Disease
Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis .

HY-N9572

Cadambine	Others	Others
Cadambine is a monoterpenoid gluco-indole alkaloid that can be isolated from Nauclea cadamba .

HY-N3204

Neoechinulin A	Apoptosis	Neurological Disease
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-128624

DS39201083	Opioid Receptor	Neurological Disease
DS39201083, a Conolidine derivative, is a potent and orally active analgesic agent. DS39201083 shows no agonist activity at the mu opioid receptor. DS39201083 can be used for the study of neurological diseases .

HY-N16452

Asperindole F	Fungal	Infection Neurological Disease
Asperindole F is an indole-diterpene alkaloid that can be isolated from the coral-associated fungi Aspergillus candidus. Asperindole F exhibits no significant regulatory activity in the model of primary cultured cortical neuronal hyperexcitation .

HY-N0117R

Indirubin (Standard) Couroupitine B (Standard); Indigo red (Standard); Indigopurpurin (Standard)	Reference Standards Apoptosis	Cancer
Indirubin (Standard) is the analytical standard of Indirubin. This product is intended for research and analytical applications. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Parasite	Infection
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-169466

5-Methoxy-N,N-dimethyltryptamine Nb-oxide	Drug Derivative	Neurological Disease
5-Methoxy-N,N-dimethyltryptamine Nb-oxide is an indole alkaloid. 5-Methoxy-N,N-dimethyltryptamine Nb-oxide is the N-oxide form of 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), which is a known psychoactive substance .

HY-120098A

Vinleurosine sulfate	Others	Cancer
Vinleurosine sulfate is an indole alkaloid with antineoplastic activity .

HY-N3281

Methyl chanofruticosinate	Others	Others
Methyl chanofruticosinate is an indole alkaloid that can be isolated from Kopsia .

HY-N0675

Anhydrovinblastine	Others	Cancer
Anhydrovinblastine is a monoterpenoid indole alkaloid that can be isolated from Catharanthus roseus leaves .

HY-N0675A

Anhydrovinblastine sulfate	Microtubule/Tubulin	Cancer
Anhydrovinblastine sulfate is a monoterpenoid indole alkaloid that can be isolated from Catharanthus roseus leaves .

HY-122189

Akuammine (-)-Akuammine; Vincamajoridine	Others	Neurological Disease
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC₅₀s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

HY-N3374

Lochnerine 10-O-Methylsarpagine	Others	Others
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .

HY-N12364

Bufoserotonin C	Others	Cancer
Bufoserotonin C is a new indole alkaloid from the traditional Chinese medicine Chansu that has antitumor activity, with IC ⁵⁰ of 34.3 μM in A549 cells .

HY-N3217

N1-Methoxymethyl picrinine	Others	Others
N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .

HY-N1018

11-Hydroxygelsenicine	Others	Others
11-Hydroxygelsenicine is a 11-hydroxy-substituted gelsedine-type indole alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans .

HY-125538

Deoxybrevianamide E	Endogenous Metabolite	Inflammation/Immunology
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N9161

Echitoveniline	Others	Cancer
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC₅₀: > 40 μM) .

HY-135743

Apovincamine cis-Apovincamine; (+)-Apovincamine	Tyrosinase	Cancer
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

HY-W665464

(Rac)-7-Ethyl-10-hydroxycamptothecin	Drug Derivative Topoisomerase	Cancer
(Rac)-7-Ethyl-10-hydroxycamptothecin is the derivative of (±)-10-Hydroxycamptothecin (HY-N0275). (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity .

HY-N16645

Plasiaticine B	Cholinesterase (ChE)	Cancer
Plasiaticine B (Compound 2) is an indole alkaloid found in Plantago asiatica. Plasiaticine B shows no significant cytotoxicity to HL-60, A-549 and MCF-7 cells with IC₅₀ >40 μM. Plasiaticine B shows no significant inhibitory effect on AChE, with an inhibition rate <60% .

HY-N7507

Sempervirine	Others	Cancer
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

HY-120098

Vinleurosine	Others	Cancer
Vinleurosine is an indole alkaloid with antineoplastic activity .

Cat. No.	Product Name

HY-L0107V

Life Chemicals Natural Product-like Compound Library

13,236 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

HY-L071

Alkaloids Library

599 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 599 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-W014971

Tryptamine hydrochloride

1 Publications Verification

Biochemical Assay Reagents

Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-W001288

Indole-4-carboxaldehyde

Biochemical Assay Reagents

Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0117

Indirubin Maximum Cited Publications 12 Publications Verification Couroupitine B; Indigo red; Indigopurpurin	Alkaloids other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Apoptosis
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids Source Classification	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-N1163

Tetrahydroalstonine (-)-Tetrahydroalstonine	Apocynaceae Alkaloids Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Adrenergic Receptor Atg8/LC3 Akt mTOR
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury .

HY-N2193

Hirsutine 1 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Infection Alkaloids Classification of Application Fields Rubiaceae Plants Disease Research Fields Indole Alkaloids Source Classification	Flavivirus Dengue Virus Apoptosis
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .

HY-N6607

Tryptanthrin 5+ Cited Publications	Alkaloids Classification of Application Fields Polygonaceae Plants Polygonum tinctorium Ait. Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N3536

Canthin-6-one	Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Zanthoxylum stenophyllum Hemsl. Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Bacterial NO Synthase COX Akt NF-κB
Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities .

HY-B1021

Vincamine 1 Publications Verification	Apocynaceae Cardiovascular Disease Alkaloids Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Free Fatty Acid Receptor
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Alkaloids Monophenols Pyrrole Alkaloids Classification of Application Fields Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N11478

Villocarine A	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids Source Classification	Others
Villocarine A is a natural vasorelaxant indole alkaloid .

HY-N2197

Hirsuteine 2 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Neurological Disease Classification of Application Fields Rubiaceae Plants Disease Research Fields Indole Alkaloids Source Classification	nAChR
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-N6776

Penitrem A	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Potassium Channel
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .

HY-N6932

Voacamine	Alkaloids other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	Cannabinoid Receptor P-glycoprotein PI3K Akt mTOR Apoptosis Autophagy EGFR
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .

HY-121002

Alstonine	Apocynaceae Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Pyridine Alkaloids Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Source Classification	Parasite
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Structural Classification Alkaloids Solanum melongena L. Solanaceae Plants Indole Alkaloids Source Classification	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N3797A

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Classification of Application Fields Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer Source Classification	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-A0220

Rescinnamine 1 Publications Verification Reserpinine	Apocynaceae Alkaloids Piperidine Alkaloids Rauvolfia serpentina other families Classification of Application Fields Other Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	Drug Derivative
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .

HY-N10149

Nauclefine	Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Rubiaceae Plants Indole Alkaloids Source Classification	Phosphodiesterase (PDE) Apoptosis
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway .

HY-N6607R

Tryptanthrin (Standard)	Alkaloids Structural Classification Polygonaceae Plants Polygonum tinctorium Ait. Indole Alkaloids Source Classification	Reference Standards Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N11665

Donasine	Alkaloids Gramineae Plants Arundo donax Linn. Indole Alkaloids Source Classification	Others
Donasine, indole alkaloid, is a nature product with effect of reducing fever. Donasine can be isolated from the rhizomes of Arundo donax L .

HY-N16411

Carneamide A	Alkaloids Microorganisms Indole Alkaloids Source Classification	Others
Carneamide A is a prenylated indole alkaloid produced by a marine-derived Aspergillus sp .

HY-N16573

19-epi-Voacristine	Apocynaceae Structural Classification Alkaloids Tabernaemontana bovina Loureiro Plants Indole Alkaloids Source Classification	Others
19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .

HY-N9164

Hecubine	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Tabernaemontana bufalina Lour. Plants Source Classification	TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .

HY-N11479

Vallesiachotamine	Apocynaceae Alkaloids Melodinus suaveolens (Hance) Champ. ex Benth. Plants Indole Alkaloids Source Classification	Apoptosis Necroptosis
Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity .

HY-N9572

Cadambine	Structural Classification Alkaloids Other Monoterpenes Terpenoids Rubiaceae Neolamarckia cadamba (Roxb.) Bosser Plants Indole Alkaloids Source Classification	Others
Cadambine is a monoterpenoid gluco-indole alkaloid that can be isolated from Nauclea cadamba .

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Indole Alkaloids Source Classification	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-N16452

Asperindole F	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Fungal
Asperindole F is an indole-diterpene alkaloid that can be isolated from the coral-associated fungi Aspergillus candidus. Asperindole F exhibits no significant regulatory activity in the model of primary cultured cortical neuronal hyperexcitation .

HY-N0117R

Indirubin (Standard) Couroupitine B (Standard); Indigo red (Standard); Indigopurpurin (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Reference Standards Apoptosis
Indirubin (Standard) is the analytical standard of Indirubin. This product is intended for research and analytical applications. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Alkaloids Aspidosperma ulei Markgr. Plants Indole Alkaloids Source Classification	Parasite
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-N3281

Methyl chanofruticosinate	Apocynaceae Alkaloids Plants Indole Alkaloids Source Classification Kopsia Blume	Others
Methyl chanofruticosinate is an indole alkaloid that can be isolated from Kopsia .

HY-N0675

Anhydrovinblastine	Apocynaceae Alkaloids Classification of Application Fields Other Diseases Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Others
Anhydrovinblastine is a monoterpenoid indole alkaloid that can be isolated from Catharanthus roseus leaves .

HY-N3374

Lochnerine 10-O-Methylsarpagine	Apocynaceae Alkaloids Alstonia macrophylla Wall. ex G. Don Plants Source Classification	Others
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .

HY-N12364

Bufoserotonin C	Alkaloids Animals Indole Alkaloids Source Classification	Others
Bufoserotonin C is a new indole alkaloid from the traditional Chinese medicine Chansu that has antitumor activity, with IC ⁵⁰ of 34.3 μM in A549 cells .

HY-N3217

N1-Methoxymethyl picrinine	Apocynaceae Alkaloids Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids Source Classification	Others
N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .

HY-125538

Deoxybrevianamide E	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Marine natural products Endogenous metabolite Marine microorganism Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N9161

Echitoveniline	Apocynaceae Alkaloids Other Monoterpenes Terpenoids Alstonia mairei Lévl. Plants Indole Alkaloids Source Classification	Others
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC₅₀: > 40 μM) .

HY-135743

Apovincamine cis-Apovincamine; (+)-Apovincamine	Apocynaceae Alkaloids Alstonia yunnanensis Diels Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Tyrosinase
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

HY-N16645

Plasiaticine B	Plantaginaceae Structural Classification Alkaloids Plantago asiatica L. Plants Indole Alkaloids Source Classification	Cholinesterase (ChE)
Plasiaticine B (Compound 2) is an indole alkaloid found in Plantago asiatica. Plasiaticine B shows no significant cytotoxicity to HL-60, A-549 and MCF-7 cells with IC₅₀ >40 μM. Plasiaticine B shows no significant inhibitory effect on AChE, with an inhibition rate <60% .

HY-N7507

Sempervirine	Alkaloids Classification of Application Fields Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Cancer Source Classification	Others
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

HY-120098

Vinleurosine	Apocynaceae Alkaloids Plants Source Classification Catharanthus roseus (L.) G. Don	Others
Vinleurosine is an indole alkaloid with antineoplastic activity .

HY-N4032

Humantenidine	Alkaloids other families Classification of Application Fields Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	Others
Humantenidine, an indole alkaloid, is isolated from Gelsemium sempervirens.

HY-N2030

Perakine	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Alkaloids Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Others
Perakine is an indole alkaloid with anti-inflammatory activities .

HY-N11803

Arundanine	Alkaloids Gramineae Plants Arundo donax Linn. Indole Alkaloids Source Classification	Others
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .

HY-N7508

Humantenirine	Alkaloids Classification of Application Fields Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Inflammation/Immunology Indole Alkaloids Source Classification	Others
Humantenirine is an indole alkaloid isolated from Gelsemium sempervirens .

HY-119642

Kopsinine	Apocynaceae Terpenoids Diterpenoids Vinca erecta Regel & Schmalh. Plants Source Classification	Others
Kopsinine is an indole alkaloid extracted from periwinkle flowers .

HY-N1099

Vellosimine (+)-Vellosimine; alkaloid RB 19	Alkaloids other families Pteris wallichiana Agardh Plants Indole Alkaloids Source Classification	Others
Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .

HY-N9374

Bufotenidine	Alkaloids Animals Indole Alkaloids Source Classification	5-HT Receptor
Bufotenidine, a natural indole alkaloid, is a blocking agent of the tryptaminic receptors .

HY-129568

Tetraphyllicine	Apocynaceae Alkaloids Other Alkaloids Rauvolfia vomitoria Afzel. Plants Source Classification	Others
Tetraphyllicine is an alkaloid, which can be isolated from Rauwolfia tetraphylla L. Tetraphyllicine can be used in research about the biosynthetic relationship of indole and indoline alkaloids .

HY-N1948

Mitoridine	Alkaloids Monophenols other families Pyrrole Alkaloids Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Indole Alkaloids Source Classification	Others
Mitoridine is an indole alkaloid compound isolated from the stem bark of Rauwolfia cumminsii Stapf .

HY-N12187

5,22-Dioxokopsane	Apocynaceae Alkaloids Plants Kopsia arborea Blume Indole Alkaloids Source Classification	Others
5,22-Dioxokopsane is a monoterpenoid indole alkaloid derived from Kopsia officinalis .

Cat. No.	Product Name	Chemical Structure

HY-W001288S

Indole-4-carboxaldehyde-13C

Indole-4-carboxaldehyde- ¹³C is the ¹³C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis .

HY-W014971S

Tryptamine-d2-1 hydrochloride

Tryptamine-d₂-1 hydrochloride is the deuterium labeled Tryptamine hydrochloride (HY-W014971). Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

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