Strictosidinic acid 

Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice^[1][2].

Strictosidinic acid (20 μg/μl; intra-hippocampal injection) causes a significance of 83.5% reduction in 5-HT levels. Strictosidinic acid (10 mg/kg; i.p.) causes a 63.4% reduction in 5-HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

516.54

Solid

C₂₆H₃₂N₂O₉

150148-81-5

O=C(C1=CO[[email protected]@H](O[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O2)O)O)O)[[email protected]](C=C)[[email protected]@H]1C[[email protected]@H]3NCCC4=C3NC5=C4C=CC=C5)O

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. F M Farias, et al. Strictosidinic Acid, Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae), Decreases Serotonin Levels in Rat Hippocampus. Fitoterapia. 2012 Sep;83(6):1138-43.  [Content Brief]

  [2]. F M Farias, et al. Monoamine Levels in Rat Striatum After Acute Intraperitoneal Injection of Strictosidinic Acid Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae). Phytomedicine. 2010 Mar;17(3-4):289-91.  [Content Brief]