Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)

  • Phytomedicine. 2010 Mar;17(3-4):289-91. doi: 10.1016/j.phymed.2009.05.008.
F M Farias  1 ,  C S Passos ,  M D Arbo ,  J A S Zuanazzi ,  V M Steffen ,  A T Henriques
Affiliations
  • 1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul. Av. Ipiranga, 2752, CEP 90610-000 Porto Alegre, RS, Brazil.
PMID: 19576739 DOI: 10.1016/j.phymed.2009.05.008
Abstract

Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.

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