Marcfortine A
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
For research use only. We do not sell to patients.
- CAS No.: 75731-43-0
- Formula: C28H35N3O4
- Molecular Weight:477.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 75731-43-0
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Molecular Weight 477.60
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Formula C28H35N3O4
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SMILES
CN1[C@]23[C@](C[C@]4(N(CCCC4)C3)C1=O)([H])C(C)([C@@]5(C6=CC=C(OC(C)(C)C=CO7)C7=C6NC5=O)C2)C
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Synonyms
NSC 324645
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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