75731-43-0
Chemical Structure
Marcfortine A
Synonym(s): NSC 324645
- CAS No.: 75731-43-0
- Formula:C28H35N3O4
- Molecular Weight:477.60
IUPAC Name: (3a'S,8R,9a'S,10a'S)-1',1',4,4,12'-pentamethyl-6',7',8',9',10',10a'-hexahydro-1'H,3'H,4H,4'H-spiro[[1,4]dioxepino[2,3-g]indole-8,2'-[3a,9a](epiminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione
InChIKey: KYKUTNUWXQVSSU-ZALBMCOMSA-N
SMILES: CN1[C@]23[C@](C[C@]4(N(CCCC4)C3)C1=O)([H])C(C)([C@@]5(C6=CC=C(OC(C)(C)C=CO7)C7=C6NC5=O)C2)C
Biological Activity: Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
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Marcfortine A | Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively. | |||||||||||||||||||||
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Keywords
