1. Hirsuteine

Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.

For research use only. We do not sell to patients.

Hirsuteine Chemical Structure

Hirsuteine Chemical Structure

CAS No. : 35467-43-7

Size Price Stock Quantity
1 mg USD 65 In-stock
5 mg USD 160 In-stock
10 mg USD 240 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes[1].

Molecular Weight

366.45

Formula

C22H26N2O3

CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(OC)/C([C@H]([C@H](CN1CC2)C=C)C[C@]1([H])C3=C2C(C=CC=C4)=C4N3)=C/OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (272.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7289 mL 13.6444 mL 27.2889 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7289 mL 13.6444 mL 27.2889 mL 68.2221 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL 13.6444 mL
10 mM 0.2729 mL 1.3644 mL 2.7289 mL 6.8222 mL
15 mM 0.1819 mL 0.9096 mL 1.8193 mL 4.5481 mL
20 mM 0.1364 mL 0.6822 mL 1.3644 mL 3.4111 mL
25 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7289 mL
30 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2741 mL
40 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7056 mL
50 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3644 mL
60 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1370 mL
80 mM 0.0341 mL 0.1706 mL 0.3411 mL 0.8528 mL
100 mM 0.0273 mL 0.1364 mL 0.2729 mL 0.6822 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Hirsuteine
Cat. No.:
HY-N2197
Quantity:
MCE Japan Authorized Agent: