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  3. Alstonine

Alstonine 

Cat. No.: HY-121002
Handling Instructions

Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.

For research use only. We do not sell to patients.

Alstonine Chemical Structure

Alstonine Chemical Structure

CAS No. : 642-18-2

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Description

Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1].

In Vitro

Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues[1].

In Vivo

In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg[1].
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages[1].
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells[1].

Molecular Weight

348.40

Formula

C₂₁H₂₀N₂O₃

CAS No.

642-18-2

SMILES

COC(C1=CO[[email protected]@H](C)[[email protected]@]2([H])[[email protected]]1([H])CC3=[N+](C2)C=CC4=C3[N-]C5=C4C=CC=C5)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AlstonineParasiteRemedyindolealkaloidantipsychoticanxiolyticanticancerantimalarialInhibitorinhibitorinhibit

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