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Cat. No.: HY-N16404

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Asperindole A

Asperindole A is an indole-diterpene alkaloid. Asperindole A can be isolated from fungus Aspergillus sp. KMM 4676. Asperindole A induces Apoptosis. Asperindole A exerts cytotoxic activity against hormone-resistant and hormone-sensitive prostate cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2416222-17-6
Formula: C₂₉H₃₂ClNO₆
Molecular Weight:526.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Asperindole A Chemical Structure

CAS No.: 2416222-17-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

Fungal Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

Asperindole A potently reduces viability of PC-3, LNCaP, and 22Rv1 human prostate cancer cells with IC₅₀ values of 69.4 μM, 47.8 μM, and 4.86 μM, respectively^[1].
Asperindole A (0.3125-5 μM; 48 h) induces concentration-dependent apoptosis in 22Rv1 human prostate cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2416222-17-6
Molecular Weight 526.02
Formula C₂₉H₃₂ClNO₆
SMILES

O[C@]12C([C@@]3(CC[C@@]1([C@]4(C5=C(C6=CC=C(Cl)C=C6N5)C[C@]4([H])CC2)C)C)O[C@]7([H])[C@](C)(CO3)OC(C)=O)=CC7=O
Structure Classification
- Alkaloids
- Indole Alkaloids
- Terpenoids
- Diterpenoids
Initial Source
- Microorganisms
Aspergillus sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ivanets EV, et al. Asperindoles A⁻D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp. KMM 4676. Mar Drugs. 2018 Jul 9;16(7):232. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Asperindole A

All Endogenous Metabolite Isoforms