2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Asperindole A

Asperindole A is an indole-diterpene alkaloid. Asperindole A can be isolated from fungus Aspergillus sp. KMM 4676. Asperindole A induces Apoptosis. Asperindole A exerts cytotoxic activity against hormone-resistant and hormone-sensitive prostate cancer cells.

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Asperindole A

Asperindole A Chemical Structure

CAS No. : 2416222-17-6

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Asperindole A Related Antibodies

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Description

Asperindole A is an indole-diterpene alkaloid. Asperindole A can be isolated from fungus Aspergillus sp. KMM 4676. Asperindole A induces Apoptosis. Asperindole A exerts cytotoxic activity against hormone-resistant and hormone-sensitive prostate cancer cells[1].

IC50 & Target[1]

Fungal Metabolite

 

In Vitro

Asperindole A potently reduces viability of PC-3, LNCaP, and 22Rv1 human prostate cancer cells with IC50 values of 69.4 μM, 47.8 μM, and 4.86 μM, respectively[1].
Asperindole A (0.3125-5 μM; 48 h) induces concentration-dependent apoptosis in 22Rv1 human prostate cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Asperindole A Related Antibodies
Molecular Weight

526.02

Formula

C29H32ClNO6
CAS No.
SMILES

O[C@]12C([C@@]3(CC[C@@]1([C@]4(C5=C(C6=CC=C(Cl)C=C6N5)C[C@]4([H])CC2)C)C)O[C@]7([H])[C@](C)(CO3)OC(C)=O)=CC7=O
Structure Classification
Initial Source

Aspergillus sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Asperindole A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asperindole A2416222-17-6ApoptosisEndogenous MetaboliteapoptosisAspergillus sp. KMM 467622Rv1PC-3S-phase arrestLNCaPprostate cancerG2/M-phase arresthuman prostate cancer cellsInhibitorinhibitorinhibit

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