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Results for "

skin damage

" in MedChemExpress (MCE) Product Catalog:

51

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2

Biochemical Assay Reagents

5

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15

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4

Isotope-Labeled Compounds

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111355B
    Cholesteryl sulfate sodium

    		Sirtuin Endogenous Metabolite PKC AMPK DOCK Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .
    Cholesteryl sulfate sodium
  • HY-106950
    Fosfructose

    Diphosphofructose; Esafosfan; FDP

    		 Toll-like Receptor (TLR) COX Cardiovascular Disease Neurological Disease Metabolic Disease
    Fosfructose is an orally active cyclooxygenase-2 inhibitor and Toll-like receptor 4 modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the Toll-like receptor 4 signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .
    Fosfructose
  • HY-B1398
    Ampyrone
    1 Publications Verification

    4-Aminophenazone

    		 COX Drug Metabolite Neurological Disease Inflammation/Immunology Cancer
    Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
    Ampyrone
  • HY-N6821
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid

    		Drug Derivative Inflammation/Immunology Cancer
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid is an orally active glucoside derivative of ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be hydrolyzed by α-glucosidase to release ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid inhibits melanin synthesis, prevents UV-induced cell damage, and promotes collagen synthesis in skin fibroblasts. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid also induces oxidative stress to inhibit tumor growth. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be used in research related to tumors, inflammation, and other conditions .
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
  • HY-P10533
    Cysteine peptide

    		Tyrosinase Others
    Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .
    Cysteine peptide
  • HY-N2406
    Dihydrocaffeic acid
    2 Publications Verification

    3,4-Dihydroxy-benzenepropanoic acid

    		 p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology
    Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .
    Dihydrocaffeic acid
  • HY-N0260
    Epmedin C
    5+ Cited Publications

    Epimedin-C; Baohuoside-VI

    		 Keap1-Nrf2 CDK Caspase Infection Metabolic Disease Inflammation/Immunology Cancer
    Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia .
    Epmedin C
  • HY-111940
    LUT014

    		Raf p38 MAPK ERK Inflammation/Immunology
    LUT014 is a topical inhibitor targeting BRAF that cannot pass through the blood-brain barrier. LUT014 inhibits BRAF kinase and abnormally activates the MAPK/ERK signaling pathway, promoting the proliferation of epidermal keratinocytes, repairing skin barrier damage caused by radiation damage, and alleviating inflammatory responses. LUT014 is independent of RAS signaling and accelerates the repair and regeneration of damaged skin cells. LUT014 can be used to study radiation dermatitis, especially skin damage caused by breast cancer radiotherapy .
    LUT014
  • HY-B0928
    Homosalate
    1 Publications Verification

    Homomenthyl salicylate

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity .
    Homosalate
  • HY-N0729D
    Linoleic acid,suitable for cell culture

    		Glutathione Peroxidase SOD Cardiovascular Disease
    Linoleic acid is a critical component of polyunsaturated fatty acids. Linoleic acid reduces GSH-PX and T-SOD activities. Linoleic acid functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid can cause acute oxidative damage to red blood cells, ultimately leading to partial acute anemia. Linoleic acid can be used in the research of skin diseases associated with linoleic acid deficiency .
    Linoleic acid,suitable for cell culture
  • HY-111355
    Cholesterol sulfate

    		Endogenous Metabolite DOCK PKC AMPK Sirtuin Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .
    Cholesterol sulfate
  • HY-N5048
    Galloylpaeoniflorin

    6'-O-Galloyl paeoniflorin

    		 NF-κB ERK JNK Nuclear Factor of activated T Cells (NFAT) Keap1-Nrf2 PI3K Akt Reactive Oxygen Species (ROS) Apoptosis DNA/RNA Synthesis Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) is an orally active galloylated derivative of Paeoniflorin (HY-N0293) found in peony roots with various anti-inflammatory and antioxidant activities. Galloylpaeoniflorin suppresses RANKL-induced activation of ERK, JNK, c-Fos, c-Jun, and NFATc1, and reduces osteoclast-specific gene expression. Galloylpaeoniflorin activates Nrf2 and PI3K/Akt pathways, inhibits NF-κB activation, and scavenges ROS to reduce oxidative DNA, lipid, and protein damage. Galloylpaeoniflorin attenuates neuroinflammation, inhibits apoptosis, reduces Helicobacter pylori-induced gastric mucosa injury and UVB-induced cell damage. Galloylpaeoniflorin can be used for the research of osteoporosis, gastritis, ischemic stroke and skin diseases .
    Galloylpaeoniflorin
  • HY-N1407
    Polygalaxanthone III

    		Cytochrome P450 STAT Infection Inflammation/Immunology
    Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC50 of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage .
    Polygalaxanthone III
  • HY-A0169A
    Methyl aminolevulinate hydrochloride
    1 Publications Verification

    		 Reactive Oxygen Species (ROS) Photosensitizer Cancer
    Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .
    Methyl aminolevulinate hydrochloride
  • HY-N0754
    Eupalinolide A

    		YAP HSP Reactive Oxygen Species (ROS) ERK Autophagy Apoptosis Tyrosinase DNA/RNA Synthesis Neurological Disease Inflammation/Immunology Cancer
    Eupalinolide A is a Yes-associated protein (YAP) degrader and HSP70 inducer. Eupalinolide A inhibits osteogenic differentiation of tendon-derived stem cells (TDSCs). Eupalinolide A induces autophagy in hepatocellular carcinoma cells via activating the ROS/ERK signaling pathway. Eupalinolide A protects PAM212 cells from UVB-, Menadione (HY-B0332)-, or heat shock-induced apoptosis. Eupalinolide A alleviates trauma-induced heterotopic ossification (HO) of Achilles tendon and inhibits growth of MHCC97-L and HCCLM3 hepatocellular carcinoma xenograft tumors in mice. Eupalinolide A can be used for the study of traumatic heterotopic ossification of tendons and hepatocellular carcinoma .
    Eupalinolide A
  • HY-118020A
    Loliolide

    Loliolid; Digiprolactone

    		 Endogenous Metabolite Caspase PI3K Apoptosis Akt Sirtuin Reactive Oxygen Species (ROS) NF-κB MMP Neurological Disease Cancer
    Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease .
    Loliolide
  • HY-W002199
    6:2 Fluorotelomer alcohol

    6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol

    		 Bacterial Apoptosis ERK TNF Receptor Infection Neurological Disease
    6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders .
    6:2 Fluorotelomer alcohol
  • HY-W019321
    3-Butenylamine hydrochloride

    		Biochemical Assay Reagents Others
    3-Butenylamine hydrochloride can be used as an intermediate in the production of polymers, adhesives, resins and other chemicals. 3-Butenylamine hydrochloride may cause skin and eye irritation or burns, severe eye damage, and breathing problems .
    3-Butenylamine hydrochloride
  • HY-B0897
    Bisoctrizole
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Bisoctrizole is a broad-spectrum UVA/UVB absorber that belongs to the benzotriazole class of compounds. Bisoctrizole absorbs UV light through hydroxyphenyl groups, causing reversible electronic transitions, thereby converting light energy into heat energy, inhibiting UV-induced material or skin damage. Bisoctrizole is highly efficient in capturing UVA (320-400 nm) and some UVB (280-320 nm) radiation. Bisoctrizole delays the photodegradation of materials such as silicones, improving their UV aging resistance or enhancing the photoprotective ability of sunscreen products .
    Bisoctrizole
  • HY-W011168
    8-Bromo-2'-deoxyguanosine

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Inflammation/Immunology Cancer
    8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H2O2-Cl --Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .
    8-Bromo-2'-deoxyguanosine
  • HY-118157
    3,5,7-Trimethoxyflavone

    		MMP Inflammation/Immunology
    3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .
    3,5,7-Trimethoxyflavone
  • HY-Y0683A
    Petrolatum (white)

    		Biochemical Assay Reagents Infection Inflammation/Immunology
    Petrolatum (white) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (white) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (white) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (white) is used in research on atopic dermatitis and post-operative skin infections .
    Petrolatum (white)
  • HY-W764758
    3-OH-Kynurenamine dihydroiodide

    		Aryl Hydrocarbon Receptor Inflammation/Immunology
    3-OH-Kynurenamine dihydroiodide is the dihydroiodide form of 3-OH-Kynurenamine (HY-156908). 3-OH-Kynurenamine dihydroiodide is an activator for aryl hydrocarbon receptor (AhR), and thus regulates the immune response. 3-OH-Kynurenamine dihydroiodide upregulates the expressions of Ido1 and Tgfb1, ameliorates the skin inflammation in psoriasis mouse model and kidney damage in nephrotoxic lupus mouse model .
    3-OH-Kynurenamine dihydroiodide
  • HY-B1234R
    Octinoxate (Standard)

    Octyl methoxycinnamate (Standard)

    		 Reference Standards Androgen Receptor Estrogen Receptor/ERR Others
    Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .
    Octinoxate (Standard)
  • HY-111355S
    Cholesterol sulfate-d7 sodium

    		Isotope-Labeled Compounds Sirtuin Endogenous Metabolite PKC AMPK DOCK Metabolic Disease Inflammation/Immunology Cancer
    Cholesterol sulfate sodium-d7 is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC50 values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.
    Cholesterol sulfate-d7 sodium
  • HY-W591838
    Perfluoropentanesulfonic acid

    PFPeS

    		 Biochemical Assay Reagents Phosphatase Metabolic Disease
    Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin .
    Perfluoropentanesulfonic acid
  • HY-P5641
    Pleurocidin
    1 Publications Verification

    		 Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic Infection Inflammation/Immunology
    Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .
    Pleurocidin
  • HY-N15684
    Rhodoxanthin

    		Others Metabolic Disease
    Rhodoxanthin is a carotenoid. Rhodoxanthin exerts antioxidant activity via free radical scavenging and lipid peroxidation inhibition. Rhodoxanthin is promising for research of oxidative stress-related diseases (e.g., UV-induced skin damage) .
    Rhodoxanthin
  • HY-B1234A
    (E)-Octinoxate

    (E)-Octyl methoxycinnamate

    		 Estrogen Receptor/ERR Androgen Receptor Endocrinology
    (E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .
    (E)-Octinoxate
  • HY-B1398R
    Ampyrone (Standard)
    1 Publications Verification

    4-Aminophenazone (Standard)

    		 Reference Standards COX Drug Metabolite Neurological Disease Inflammation/Immunology Cancer
    Ampyrone (4-Aminophenazone) (Standard) is the analytical standard of Ampyrone (HY-B1398). This product is intended for research and analytical applications. Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
    Ampyrone (Standard)
  • HY-U00265
    3-CPs

    3-Carbethoxypsoralen; 3-Ethoxycarbonylpsoralen

    		 Bacterial Infection
    3-CPs is a monofunctional furanocoumarin and a photoprotective agent targeting Staphylococcus aureus DNA, possessesing anti-UVB lethal activity. 3-CPs competitively intercalates into DNA, forming exclusively 4',5'-furan-side mono-adducts upon UVB irradiation, and irreversibly inhibits the formation of cyclobutane pyrimidine dimers. 3-CPs prevents UVB-induced DNA damage by preferentially binding to strong (AT)n sites within the DNA, without inducing lethal interstrand DNA cross-links; the limited number of mono-adducts it induces can be efficiently repaired by bacteria. 3-CPs holds potential for use in the development of photoprotective formulations for skin diseases, as well as in studies investigating bacterial DNA photodamage repair mechanisms and the optimization of photochemotherapy safety .
    3-CPs
  • HY-B0928S
    Homosalate-d4

    Homomenthyl salicylate-d4

    		 Isotope-Labeled Compounds Others
    Homosalate-d4 is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.
    Homosalate-d4
  • HY-B0928R
    Homosalate (Standard)

    Homomenthyl salicylate (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    Homosalate (Standard) is the analytical standard of Homosalate. This product is intended for research and analytical applications. Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity .
    Homosalate (Standard)
  • HY-156908
    3-OH-Kynurenamine

    		Aryl Hydrocarbon Receptor Inflammation/Immunology
    3-OH-Kynurenamine dihydroiodide is an activator for aryl hydrocarbon receptor (AhR), and thus regulates the immune response. 3-OH-Kynurenamine dihydroiodide upregulates the expressions of Ido1 and Tgfb1, ameliorates the skin inflammation in psoriasis mouse model and kidney damage in nephrotoxic lupus mouse model .
    3-OH-Kynurenamine
  • HY-116145
    MHY884

    		Tyrosinase NF-κB Inflammation/Immunology
    MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage .
    MHY884
  • HY-P5263
    YYRADDA

    		MMP Others
    YYRADDA is a polypeptide. YYRADDA stimulates the growth of collagen in the extracellular matrix of the skin. YYRADDA improves the appearance of the skin and promotes the healing of damaged skin .
    YYRADDA
  • HY-N1407R
    Polygalaxanthone III (Standard)

    		Reference Standards Cytochrome P450 STAT Infection Inflammation/Immunology
    Polygalaxanthone III (Standard) is the analytical standard of Polygalaxanthone III (HY-N1407). This product is intended for research and analytical applications. Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC50 of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage .
    Polygalaxanthone III (Standard)
  • HY-Y0683B
    Petrolatum (yellow)

    		Biochemical Assay Reagents Infection Inflammation/Immunology
    Petrolatum (yellow) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (yellow) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (yellow) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (yellow) is used in research on atopic dermatitis and post-operative skin infections .
    Petrolatum (yellow)
  • HY-A0169
    Methyl aminolevulinate

    		Reactive Oxygen Species (ROS) Photosensitizer Cancer
    Methyl aminolevulinate is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate is applicable to research related to actinic keratosis and basal cell carcinoma .
    Methyl aminolevulinate
  • HY-155974
    MeOIstPyrd
    1 Publications Verification

    		 MDM-2/p53 Cancer
    MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction .
    MeOIstPyrd
  • HY-N13174
    Peanut procyanidin A

    		Reactive Oxygen Species (ROS) Apoptosis Inflammation/Immunology
    Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H2O2-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .
    Peanut procyanidin A
  • HY-B1398S
    Ampyrone-d3

    4-Aminoantipyrine-d3

    		 Isotope-Labeled Compounds COX Drug Metabolite Neurological Disease Inflammation/Immunology Cancer
    Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
    Ampyrone-d3
  • HY-B0897R
    Bisoctrizole (Standard)

    		Reference Standards Biochemical Assay Reagents Others
    Bisoctrizole (Standard) is the analytical standard of Bisoctrizole (HY-B0897). This product is intended for research and analytical applications. Bisoctrizole is a broad-spectrum UVA/UVB absorber that belongs to the benzotriazole class of compounds. Bisoctrizole absorbs UV light through hydroxyphenyl groups, causing reversible electronic transitions, thereby converting light energy into heat energy, inhibiting UV-induced material or skin damage. Bisoctrizole is highly efficient in capturing UVA (320-400 nm) and some UVB (280-320 nm) radiation. Bisoctrizole delays the photodegradation of materials such as silicones, improving their UV aging resistance or enhancing the photoprotective ability of sunscreen products .
    Bisoctrizole (Standard)
  • HY-N0260R
    Epmedin C (Standard)

    Epimedin-C (Standard); Baohuoside-VI (Standard)

    		 Reference Standards Keap1-Nrf2 CDK Caspase Inflammation/Immunology
    Epmedin C (Standard) is the analytical standard of Epmedin C. This product is intended for research and analytical applications. Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia .
    Epmedin C (Standard)
  • HY-W767399
    8-Bromo-2'-deoxyguanosine-13C,15N2

    		Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Cancer
    8-Bromo-2'-deoxyguanosine- 13C, 15N2 is the 13C- and 15N-labeled 8-Bromo-2'-deoxyguanosine (HY-W011168). 8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H2O2-Cl --Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .
    8-Bromo-2'-deoxyguanosine-13C,15N2
  • HY-W415753
    Alaptide

    VUFB-15754

    		 Drug Derivative Neurological Disease Inflammation/Immunology
    Alaptide, a spirocyclic synthetic dipeptide and a derivative of melanocyte-stimulating hormone release-inhibiting factor (MIF), is a transdermal permeation modifier. Alaptide loaded on nanofibrous membranes accelerates the healing of skin incisions, particularly the healing of skin burns. Alaptide is a nootropic agent, that influences the dopaminergic system and increases homovanillic acid level in the striatum of rat models. Alaptide can be used for wound healing with large damaged areas and neurological diseases research .
    Alaptide
  • HY-W585837
    3-Benzylidenecamphor

    		Endogenous Metabolite
    3-Benzylidenecamphor is a UV absorber with excellent photostability and antioxidant activity. 3-Benzylidenecamphor is widely used in sunscreen products to protect the skin from UV damage. 3-Benzylidenecamphor can also be used in cosmetics to improve the shelf life and safety of the product.
    3-Benzylidenecamphor
  • HY-P11638
    Mitochondrial-targeted peptide BP29

    		Mitochondrial Metabolism Neurological Disease Inflammation/Immunology
    Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia .
    Mitochondrial-targeted peptide BP29
  • HY-P11638A
    Mitochondrial-targeted peptide BP29 acetate

    		Mitochondrial Metabolism Neurological Disease Inflammation/Immunology
    Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia .
    Mitochondrial-targeted peptide BP29 acetate
  • HY-A0169AR
    Methyl aminolevulinate hydrochloride (Standard)

    		Reactive Oxygen Species (ROS) Reference Standards Photosensitizer Inflammation/Immunology Cancer
    Methyl aminolevulinate hydrochloride (Standard) is the analytical standard of Methyl aminolevulinate hydrochloride. This product is intended for research and analytical applications. Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .
    Methyl aminolevulinate hydrochloride (Standard)

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