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LUT014 

Cat. No.: HY-111940
Handling Instructions

LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 .

For research use only. We do not sell to patients.

LUT014 Chemical Structure

LUT014 Chemical Structure

CAS No. : 2274819-46-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 291 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 [1].

IC50 & Target[1]

B-Raf

11.7 nM (IC50)

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8922 mL 9.4609 mL 18.9218 mL
5 mM 0.3784 mL 1.8922 mL 3.7844 mL
10 mM 0.1892 mL 0.9461 mL 1.8922 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

528.49

Formula

C₂₇H₁₉F₃N₈O

CAS No.

2274819-46-2

SMILES

FC(F)(F)OC1=CC(NC2=NC=CC3=C2C=CC(C)=C3NC4=NC=CC=C4C5=C6N=CNC6=NC=N5)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
LUT014
Cat. No.:
HY-111940
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LUT014

Cat. No.: HY-111940