2. Apoptosis Cell Cycle/DNA Damage Others
  3. Apoptosis Ferroptosis DNA/RNA Synthesis IRE1 CDK Caspase Drug Derivative
  4. Ironomycin

Ironomycin is a derivative of Salinomycin (HY-15597). Ironomycin exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin blocks the cell cycle and induces apoptosis and ferroptosis. Ironomycin induces double-strand DNA breaks and activates the unfolded protein response (UPR), particularly the IRE1α signaling pathway accumulation. The combination of Ironomycin with Ibrutinib (HY-10997) shows a synergistic effect. Ironomycin can be used for the study of MCL.

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Ironomycin

Ironomycin Chemical Structure

CAS No. : 1884647-72-6

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Ironomycin Related Antibodies

Top Publications Citing Use of Products

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Ironomycin is a derivative of Salinomycin (HY-15597). Ironomycin exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin blocks the cell cycle and induces apoptosis and ferroptosis. Ironomycin induces double-strand DNA breaks and activates the unfolded protein response (UPR), particularly the IRE1α signaling pathway accumulation. The combination of Ironomycin with Ibrutinib (HY-10997) shows a synergistic effect. Ironomycin can be used for the study of MCL.

IC50 & Target[2]

CDK4/cyclin D2

 

Cdk4/cyclin D1

 

Caspase 3

 

Caspase 8

 

Caspase 9

 

Molecular Weight

788.06

Formula

C45H73NO10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CCN[C@H]1[C@@]2(O[C@@](CC2)([C@]3([H])O[C@H]([C@](O)(CC3)CC)C)C)O[C@]4(C=C1)O[C@]([C@H](C[C@H]4C)C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@@H]([C@]5([H])O[C@@](CC[C@@H]5C)([H])[C@@H](CC)C(O)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (63.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2689 mL 6.3447 mL 12.6894 mL
5 mM 0.2538 mL 1.2689 mL 2.5379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2689 mL 6.3447 mL 12.6894 mL 31.7235 mL
5 mM 0.2538 mL 1.2689 mL 2.5379 mL 6.3447 mL
10 mM 0.1269 mL 0.6345 mL 1.2689 mL 3.1723 mL
15 mM 0.0846 mL 0.4230 mL 0.8460 mL 2.1149 mL
20 mM 0.0634 mL 0.3172 mL 0.6345 mL 1.5862 mL
25 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
30 mM 0.0423 mL 0.2115 mL 0.4230 mL 1.0574 mL
40 mM 0.0317 mL 0.1586 mL 0.3172 mL 0.7931 mL
50 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
60 mM 0.0211 mL 0.1057 mL 0.2115 mL 0.5287 mL
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Ironomycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ironomycin1884647-72-6ApoptosisFerroptosisDNA/RNA SynthesisIRE1CDKCaspaseDrug DerivativeInositol requiring enzyme 1Cyclin dependent kinaseDrug derivativeiron metabolismmantle cell lymphomaironomycindrug combinationB-cell receptor signalingInhibitorinhibitorinhibit

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