Propylparaben sodium  (Synonyms: Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium)

Propylparaben (Propyl parahydroxybenzoate) sodium is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben sodium is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury^{[1][2][3][4][5]}.

Propylparaben sodium shows weak estrogenic activity, with a potency approximately 30,000-fold less than 17β-estradiol^[1].
Propylparaben sodium disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propylparaben (0-1% in diet; dietary; continuous; 28 days) sodium disrupts male reproductive function in immature rats, causing dose-dependent reductions in sperm parameters and serum testosterone^[1].
Propylparaben (7.5 mg/kg; p.o.; daily for 8 months) sodium significantly alters the estrous cycle, hormone levels and ovarian reserve, and accelerated ovarian aging in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

202.18

C₁₀H₁₁NaO₃

35285-69-9

Solid

White to off-white

O=C(OCCC)C1=CC=C(O[Na])C=C1

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Oishi S, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002;40(12):1807-1813.  [Content Brief]

  [2]. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82.  [Content Brief]

  [3]. Ji X, et al. Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life Sci. 2004;74(24):3043-3052.  [Content Brief]

  [4]. Yan W, et al. Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice. Ecotoxicol Environ Saf. 2022;235:113432.  [Content Brief]

  [5]. Gal A, et al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019;89:100-106.  [Content Brief]