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Succinate Dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Succinate Dehydrogenase (49) Aminotransferases (Transaminases) (1) Antibiotic (4) Apoptosis (12) Autophagy (2) Bacterial (11) Bcl-2 Family (1) Biochemical Assay Reagents (4) Calcium Channel (1) Caspase (3) Constitutive Androstane Receptor (2) Cytochrome P450 (2) Drug Intermediate (3) E1/E2/E3 Enzyme (2) Environmental Pollutants (9) Fluorescent Dye (1) Fungal (77) Insecticide (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (2) Mitochondrial Metabolism (11) MMP (2) NF-κB (2) NOD-like Receptor (NLR) (2) P2Y Receptor (3) Parasite (9) Phosphatase (2) Pregnane X Receptor (PXR) (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (8) Reference Standards (15) SOD (1) α-synuclein (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (3) Infection (96) Inflammation/Immunology (14) Metabolic Disease (5) Neurological Disease (5)
Click Chemistry:	Alkynes (1)

113

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended:

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119976

Boscalid 1 Publications Verification	Environmental Pollutants Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Boscalid is a **succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS** accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-Y1787

Dimethyl malonate Maximum Cited Publications 9 Publications Verification	Apoptosis	Neurological Disease
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-W012875

3-Nitropropanoic acid 4 Publications Verification β-Nitropropionic acid; Bovinocidin	Bacterial Apoptosis Autophagy	Infection Metabolic Disease Inflammation/Immunology
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of **succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis** .

HY-D0018

DCIP sodium 1 Publications Verification Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium	Biochemical Assay Reagents	Others
DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.

HY-119459

Fluopyram 1 Publications Verification	Environmental Pollutants Constitutive Androstane Receptor Parasite Caspase Fungal NF-κB Succinate Dehydrogenase Pregnane X Receptor (PXR)	Infection Cancer
Fluopyram is an orally active **succinate dehydrogenase inhibitor, antifungal** and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic .

HY-N7114A

Chloramphenicol succinate sodium 3 Publications Verification	Bacterial P2Y Receptor Succinate Dehydrogenase Drug Intermediate	Infection Inflammation/Immunology
Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .

HY-137006

MTT Formazan	Fluorescent Dye	Others
MTT Formazan is a purple water-insoluble product formed by the reduction of yellow soluble MTT by succinate dehydrogenase in the mitochondria of viable cells. The amount of MTT Formazan produced is proportional to cellular metabolic activity, and it can serve as an indicator for evaluating cell viability and proliferation. MTT Formazan exhibits solvent-dependent solubility properties, and its absorbance value can be measured by spectrophotometry to reflect cellular status. MTT Formazan also supports the assessment of cell viability in bacterial MTT assays. MTT Formazan can be used in photoacoustic microscopy to enhance the imaging effect of viable cells, especially in applications in the fields of three-dimensional cell culture and tissue engineering .

HY-W753375

Fluindapyr	Environmental Pollutants Fungal Succinate Dehydrogenase	Infection
Fluindapyr is a broad-spectrum pyrazolamide chiral fungicide of succinate dehydrogenase inhibitor (SDHIs) with broad bactericidal spectrum and good efficacy. Fluopimomide is effective against M. incognita in vitro and application of fuopimomide shows some growth promotion effect in cucumber .

HY-D0007

Blue Tetrazolium Tetrazolium blue	Biochemical Assay Reagents	Others
Blue Tetrazolium is a tetrazolium salt chromogenic dye that can be reduced to a dark blue formazan product. Blue Tetrazolium is applicable for assays such as succinate dehydrogenase activity detection and reducing sugar quantification. Blue Tetrazolium also serves as a novel corrosion inhibitor for cold-rolled steel in hydrochloric acid solutions. Blue Tetrazolium has a broad wavelength range (480-600 nm), with the maximum absorbance observed at 540 nm .

HY-B2011

Flutolanil	Environmental Pollutants Succinate Dehydrogenase Fungal Mitochondrial Metabolism	Infection
Flutolanil is a **succinate dehydrogenase** complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control .

HY-135549

Fluxapyroxad 1 Publications Verification	Environmental Pollutants Antibiotic Cytochrome P450 Fungal Succinate Dehydrogenase	Infection Inflammation/Immunology
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species .

HY-139983

SDH-IN-1 1 Publications Verification	Fungal	Infection
SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against *S. sclerotiorum* (EC₅₀ of 0.14 mg/L) .

HY-108012

ME1111	Fungal	Infection
ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the **succinate dehydrogenase** of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research .

HY-44178

Diethyl butylmalonate 1 Publications Verification	Succinate Dehydrogenase Reactive Oxygen Species (ROS)	Infection Neurological Disease Inflammation/Immunology
Diethyl butylmalonate is a competitive inhibitor of **succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS** production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀ ^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease .

HY-W775091

Isofetamid IKF-5411	Fungal Succinate Dehydrogenase	Infection
Isofetamid (IKF-5411) is a **succinate dehydrogenase** inhibitor and a fungicide. Isofetamid exhibits good control effects against various fungal diseases such as gray mold, white mold, and powdery mildew. Isofetamid is promising for research of plant fungal diseases .

HY-162142

BB2-50F	Bacterial Succinate Dehydrogenase Reactive Oxygen Species (ROS)	Infection
BB2-50F is an antimicrobial agent and **succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS*. BB2-50F inhibits succinate* oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM .

HY-148921

SDH-IN-2	Fungal	Infection
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119459R

Fluopyram (Standard)	Reference Standards Succinate Dehydrogenase Fungal Parasite Constitutive Androstane Receptor Caspase NF-κB	Infection Cancer
Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active **succinate dehydrogenase inhibitor, antifungal** and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic .

HY-139161

Penflufen	Environmental Pollutants Fungal	Infection
Penflufen is a highly efficient, broad-spectrum **succinate dehydrogenase** inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases .

HY-W516735

Sedaxane	Fungal Succinate Dehydrogenase	Infection
Sedaxane is a new broad-spectrum seed treatment fungicide. Sedaxane inhibits fungal respiration by binding to the succinate dehydrogenase complex in fungal mitochondria. Sedaxane has broad-spectrum activity against a variety of seed-borne and soil-borne fungi. Sedaxane can be used in the study of barley loose smut and barley stripe disease .

HY-169972

Succinate dehydrogenase-IN-5	Succinate Dehydrogenase	Infection
Succinate dehydrogenase-IN-5 (Compound M8) is the inhibitor for **succinate dehydrogenase*. Succinate* dehydrogenase-IN-5 interfers with the energy metabolism and growth of fungi, inhibits Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea and Fusarium graminearum with EC₅₀ < 0.3 μg/mL .

HY-133726

Bixafen	Bacterial	Infection
Bixafen, a member of the pyrazole class of fungicides, serves as a broad-spectrum agent for controlling pathogens in cereal crops by functioning as a succinate dehydrogenase inhibitor.

HY-114509

Anilazine	Bacterial	Infection Metabolic Disease
Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .

HY-149876

SDH-IN-5	Fungal	Infection
SDH-IN-5 (compound 7d) is a potent succinate dehydrogenase (SDH) inhibitor, with an IC₅₀ of 3.293 μM. SDH-IN-5 is also exhibits antifungal activity, with an EC₅₀ of 0.046 μg/mL against R. solani. SDH-IN-5 could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies .

HY-44178S

Diethyl butylmalonate-D9	Isotope-Labeled Compounds Succinate Dehydrogenase Reactive Oxygen Species (ROS)	Infection Neurological Disease Inflammation/Immunology
Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of **succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS** production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀ ^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease .

HY-162776

Succinate dehydrogenase-IN-3	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity .

HY-173021

Succinate dehydrogenase-IN-7	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-7 (Compound 2f) is a **Succinate dehydrogenase inhibitor (IC₅₀** = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity .

HY-175501

Succinate dehydrogenase-IN-11	Fungal Succinate Dehydrogenase	Infection
Succinate dehydrogenase-IN-11 (Compound A12) is a **succinate dehydrogenase inhibitor with an IC₅₀** value of 3.58 μM. Succinate dehydrogenase-IN-11 exhibits antifungal activity. Succinate dehydrogenase-IN-11 shows activity against fungi such as R. solani, B. cinerea, F. graminearum, and S. sclerotiorum in vitro. Succinate dehydrogenase-IN-11 also exerts a controlling effect on R. solani, P. pachyrhizi, and P. sorghi in vivo. Succinate dehydrogenase-IN-11 can be used in research related to antifungal applications .

HY-176140

Succinate dehydrogenase-IN-9	Fungal Succinate Dehydrogenase	Infection
Succinate dehydrogenase-IN-9 (Compound Iik) is a **succinate dehydrogenase inhibitor (IC₅₀*: 3.6 μM). Succinate* dehydrogenase-IN-9 exhibits potent inhibitory activity against various fungal species (eg: inhibits S. sclerotiorum with an EC₅₀ value of 1.14 μg/mL. Succinate dehydrogenase-IN-9 enhances the nitrate reductase activity, thereby facilitating plant growth .

HY-174456

Succinate dehydrogenase-IN-10	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-10 (Compound B5) is a RsSDH (Succinate *dehydrogenase* of R. solani) inhibitor with an IC₅₀ of 0.12 μM. Succinate dehydrogenase-IN-10 exhibits antifungal activity against R. solani (EC₅₀ of 0.002 μg/mL) and P. pachyrhizi .

HY-169965

Succinate dehydrogenase-IN-4	Succinate Dehydrogenase	Infection
Succinate dehydrogenase-IN-4 (Compound 4b) is the inhibitor for **succinate dehydrogenase with an IC₅₀** of 3.38 μM. Succinate dehydrogenase-IN-4 exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare with EC₅₀ of 16.33 μM and 18.06 μM .

HY-163890

Succinate dehydrogenase-IN-2	Succinate Dehydrogenase Parasite	Infection
Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for **succinate dehydrogenase (SDH) with an IC₅₀** of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC₅₀ of 0.52-3.42 mg/L .

HY-139839

Y12196	Fungal	Infection
Y12196 is a novel succinate dehydrogenase inhibitor (SDHI) which exhibits strong fungicidal activity against F. graminearum.

HY-N7114

Chloramphenicol succinate	Bacterial Drug Intermediate P2Y Receptor Succinate Dehydrogenase	Infection Inflammation/Immunology
Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .

HY-172363

Succinate dehydrogenase-IN-6	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for **succinate dehydrogenase that inhibits SDH** in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL) .

HY-162648

Succinate dehydrogenase-IN-1	Fungal	Infection
Succinate dehydrogenase-IN-1 (Compound 34) is an inhibitor for **succinate dehydrogenase (SDH) with an IC₅₀ of 0.94 μM and a K_D** of 22.4 μM. Succinate dehydrogenase-IN-1 exhibits antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC₅₀ of 0.04 μM, 1.13 μM, 1.61 μM and 1.21 μM, respectively .

HY-172810

Succinate dehydrogenase-IN-8	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC₅₀=0.1843 mg/L), Botrytis cinerea (EC₅₀=0.4829 mg/L), and Sclerotinia sclerotiorum (EC₅₀=0.1349 mg/L) .

HY-120183

Harzianopyridone	Fungal	Infection
Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .

HY-106371

Siccanin	Antibiotic Fungal	Infection
Siccanin is a **succinate dehydrogenase (SDH) inhibitor (IC₅₀**=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi .

HY-Y1787R

Dimethyl malonate (Standard)	Reference Standards Apoptosis	Neurological Disease
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-19688B

Sitamaquine tosylate WR 6026 tosylate	Parasite Mitochondrial Metabolism	Infection
Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .

HY-149323

SDH-IN-4	Fungal	Infection
SDH-IN-4 (compound B6) is a selective inhibitor against succinate dehydrogenase (SDH) with an IC₅₀ value of 0.28 μg/mL. SDH-IN-4 has highly efficient and broad-spectrum antifungal activity, against R. solani with an EC₅₀ value of 0.23 μg/mL .

HY-178778

SDH-IN-38	Fungal	Infection
SDH-IN-38 (Compound IIIe) is a **Succinate dehydrogenase inhibitor. SDH-IN-38 is an antifungal agent, with an EC₅₀** value of 0.009 μg/mL against R. solani mycelia. SDH-IN-38 inhibits mycelial growth by affecting mycelial respiration. SDH-IN-38 induces cellular senescenc and reduces mitochondrial membrane potential in mycelia .

HY-157218

PPm	Fungal	Inflammation/Immunology Cancer
PPm, a derivative of penthiopyrad and hapten, is a representative member of the **succinate dehydrogenase** inhibitors group of fungicides .

HY-149601

SDH-IN-8	Fungal	Infection
SDH-IN-8 (compound G40) is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 27 nM for porcine SDH. SDH-IN-8 has fungicidal properties .

HY-149600

SDH-IN-7	Fungal	Infection
SDH-IN-7 (compound G28) is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 26 nM for porcine SDH. SDH-IN-7 has fungicidal properties .

HY-156270

SDH-IN-9	Bacterial	Infection
SDH-IN-9 (compound Ip) is a potent inhibitor of **Succinate Dehydrogenase*. SDH-IN-9 shows fungicidal activity against Fusarium graminearum Schw* with the EC₅₀ of 0.93 μg/mL .

HY-119976R

Boscalid (Standard)	Reference Standards Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a **succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS** accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-159481

SDH-IN-17	Succinate Dehydrogenase Fungal	Infection Inflammation/Immunology
SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC₅₀=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research .

HY-178050

SDH-IN-30	Fungal Succinate Dehydrogenase	Infection
SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research .

Cat. No.	Product Name	Type

HY-D0018

DCIP sodium

1 Publications Verification

Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium

Fluorescent Dyes

DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.

HY-D0018R

DCIP sodium (Standard)

Dichlorophenylindophenol sodium (Standard); DCPIP sodium (Standard); Indochlorophenol sodium (Standard)

Fluorescent Dyes

DCIP (sodium) (Standard) is the analytical standard of DCIP (sodium). This product is intended for research and analytical applications. DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.

Cat. No.	Product Name	Type

HY-119976

Boscalid

1 Publications Verification

Biochemical Assay Reagents

Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-D0007

Blue Tetrazolium

Tetrazolium blue

Biochemical Assay Reagents

Blue Tetrazolium is a tetrazolium salt chromogenic dye that can be reduced to a dark blue formazan product. Blue Tetrazolium is applicable for assays such as succinate dehydrogenase activity detection and reducing sugar quantification. Blue Tetrazolium also serves as a novel corrosion inhibitor for cold-rolled steel in hydrochloric acid solutions. Blue Tetrazolium has a broad wavelength range (480-600 nm), with the maximum absorbance observed at 540 nm .

HY-119976R

Boscalid (Standard)

Biochemical Assay Reagents

Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1787

Dimethyl malonate Maximum Cited Publications 9 Publications Verification	Structural Classification Natural Products Melia azedarach L. Plants Meliaceae Source Classification	Apoptosis
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-W012875

3-Nitropropanoic acid 4 Publications Verification β-Nitropropionic acid; Bovinocidin	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Source Classification	Bacterial Apoptosis Autophagy
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of **succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis** .

HY-113298

Citraconic acid 4 Publications Verification Methylmaleic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

HY-N7114A

Chloramphenicol succinate sodium 3 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial P2Y Receptor Succinate Dehydrogenase Drug Intermediate
Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .

HY-W134163

(E)-2-Octenal trans-2-Octenal	Structural Classification Natural Products Vitis vinifera cv. Zalema Plants Vitaceae Source Classification	Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase
(E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .

HY-N7114

Chloramphenicol succinate	Structural Classification Microorganisms Antibiotics Disease Research Other Antibiotics Source Classification	Bacterial Drug Intermediate P2Y Receptor Succinate Dehydrogenase
Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .

HY-120183

Harzianopyridone	Natural Products Microorganisms Source Classification	Fungal
Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .

HY-Y1787R

Dimethyl malonate (Standard)	Structural Classification Natural Products Melia azedarach L. Plants Meliaceae Source Classification	Reference Standards Apoptosis
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-N7114AR

Chloramphenicol succinate sodium (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Drug Intermediate P2Y Receptor Succinate Dehydrogenase
Chloramphenicol succinate sodium (Standard) is the analytical standard of Chloramphenicol succinate sodium. This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .

HY-W007972R

Methyl 3-methoxyacrylate (Standard) 3-Methoxyacrylic Acid Methyl Ester (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Others
Anilazine (Standard) is the analytical standard of Anilazine. This product is intended for research and analytical applications. Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .

HY-W012875R

3-Nitropropanoic acid (Standard) β-Nitropropionic acid (Standard); Bovinocidin (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards Bacterial Apoptosis Autophagy
3-Nitropropanoic acid (Standard) is the analytical standard of 3-Nitropropanoic acid. This product is intended for research and analytical applications. 3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis[1][2].

HY-113298R

Citraconic acid (Standard) Methylmaleic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

HY-114625

Amquinate	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Parasite Mitochondrial Metabolism
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection) .

HY-N17816

Tambulin	Structural Classification Flavonoids Flavones Rutaceae Plants Zanthoxylum armatum DC. Source Classification	Apoptosis Reactive Oxygen Species (ROS) α-synuclein Succinate Dehydrogenase Bcl-2 Family Caspase
Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes .

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HY-P704801

	SDHA Protein, Human (His) Succinate Dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; SDHA; Flavoprotein subunit of complex II (Fp); Malate Dehydrogenase [quinone] flavoprotein subunit;	Human	E. coli
	SDHA Protein, Human (His) is the recombinant human-derived SDHA protein, expressed by E. coli, with C-6*His tag.

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HY-44178S

Diethyl butylmalonate-D9

Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀ ^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease .

HY-119976S

Boscalid-d4

Boscalid-d₄ is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (4) ICC/IF (2) IP (3) WB (4) FC (1) ELISA (2)
Isotype:	IgG (3) IgG/Kappa (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

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HY-P87067

	SDHC Antibody(YA6760) CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; sdhC antibody; Succinate dehydrgenase cytochrome b antibody; Succinate Dehydrogenase 3, integral membrane subunit antibody; Succinate Dehydrogenase complex subunit C antibody; Succinate Dehydrogenase complex subunit C integral membrane protein 15kDa antibody; Succinate Dehydrogenase cytochrome b560 subunit antibody; Succinate Dehydrogenase cytochrome b560 subunit mitochondrial antibody; Succinate Dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody; Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody;	WB, IHC-P	Human, Mouse, Rat
	SDHC Antibody(YA6760) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHC.

HY-P86640

	SDHA Antibody (YA6332) SDHA; SDH2; SDHF; Succinate Dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial; Flavoprotein subunit of complex II; Fp	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SDHA Antibody (YA6332) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHA.

HY-P81835

	SDHB Antibody (YA1580) SDHB; SDH; SDH1; Succinate Dehydrogenase [ubiquinone] iron-sulfur subunit; mitochondrial; Iron-sulfur subunit of complex II; Ip	WB, IHC-P, IP, FC	Human, Mouse, Rat
	SDHB Antibody (YA1580) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHB.

HY-P86391

	SDHB Antibody (YA6083) SDHB; SDH; SDH1; Succinate Dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SDHB Antibody (YA6083) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHB.

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Cat. No.	Product Name		Classification

HY-148921

SDH-IN-2		Alkynes
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Succinate Dehydrogenase

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