Sitamaquine hydrochloride
Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes.
For research use only. We do not sell to patients.
- CAS No.: 5330-29-0
- Formula: C21H35Cl2N3O
- Molecular Weight:416.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 5330-29-0
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Molecular Weight 416.43
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Formula C21H35Cl2N3O
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SMILES
COC1=CC2=C(C)C=CN=C2C(NCCCCCCN(CC)CC)=C1.Cl.Cl
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Synonyms
WR 6026 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036. [Content Brief]
[2]. Luis Carvalho, et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sitamaquine hydrochloride Related Classifications
HY-19688A Related Classifications
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