5330-29-0
Chemical Structure
Sitamaquine hydrochloride
Synonym(s): WR 6026 hydrochloride
- CAS No.: 5330-29-0
- Formula:C21H35Cl2N3O
- Molecular Weight:416.43
IUPAC Name: N1,N1-diethyl-N6-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine dihydrochloride
InChIKey: AFMFKGVIHLNIEO-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C)C=CN=C2C(NCCCCCCN(CC)CC)=C1.Cl.Cl
Biological Activity: Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1][2].
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Sitamaquine hydrochloride | Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes. | |||||||||||||||||||||
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- [1]. López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036. [Content Brief]
- [2]. Luis Carvalho, et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. [Content Brief]
Keywords
