SDH-IN-32
SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C17H21FN2O3
- 分子量:320.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
SDH-IN-32 (Compound A2) exhibits excellent antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Botrytis cinerea, Gibberella zeae, and Physalospora piricola, with EC50 values of 0.133, 0.258, 0.428, 0.519, 1.29, and 1.51 μg/mL, respectively[1].
SDH-IN-32 (200 μg/mL) shows protective efficacies of 76.1 against rice sheath blight, 64.5% against B. cinerea on tomato fruits and 67.7% against V. mali on apple fruits[1].
SDH-IN-32 (0.133 μg/mL) destroys the cell membrane structure, increases the permeability of the cell membrane and decreases the MMP in R. solani[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Research Protocol for Infectious Diseases
- Mitochondrial membrane-potential fluorescent assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Fluorescent plasma-membrane potential dye assay
- Mitochondrial membrane-potential and mitochondrial mass staining
- Transepithelial/transendothelial electrical resistance assay
- Apoptosis Solutions
化学情報
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分子量 320.36
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分子式 C17H21FN2O3
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SMILES
O=C(NNC1=CC=C(F)C=C1)COC2=C(C)CC(C)(C)CC2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SDH-IN-32 関連分類
HY-178196 関連分類
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