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Cat. No.: HY-161504

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SDH-IN-14

SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC₅₀=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₀N₄O₂S₂
Molecular Weight:424.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SDH-IN-14 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

SDH-IN-14 (0-100 μg/mL; 12 h) in B.cinerea reveals that cell membrane permeability increased with increasing concentration^[1].
SDH-IN-14 (0-200 μg/mL; 10 h) in B.cinerea shows an increase in MDA content with increasing concentration and oxidative damage to the cell membrane^[1].
SDH-IN-14 (12.5-100 μg/mL; 24 h) in B.cinerea shows a concentration-dependent inhibition of SDH activity^[1].
SDH-IN-14 shows antifungal activity of inhibition rat=96.7% (B.cinerea); 52.6% (R.solani); 69.9% (P.capsici); 59.2% (=S.sclerotiorum); 34.5% (=F.graminearum); 70.6% (Tomato Botrytis cinerea); 15.0% (=F.asiaticum), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SDH-IN-14 (100; 200 μg/mL) shows good antifungal activity on blueberry leaves, superior to Azoxystrobin (HY-B0849) and Fluopyram (HY-119459)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 424.54
Formula C₂₁H₂₀N₄O₂S₂
SMILES

O=C(NC1=NN=C(SCC(O)CN2C=CC3=C2C=CC=C3)S1)C4=CC=CC=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He B, et al. Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole. J Agric Food Chem. 2024 May 8;72(18):10227-10235. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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