2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. H111-H7

H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia–reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research.

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H111-H7

H111-H7 Chemical Structure

CAS No. : 220965-54-8

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Based on 1 publication(s) in Google Scholar

H111-H7 Related Antibodies

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Description

H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia–reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research[1].

IC50 & Target[1]

WWP2

717 nM (Kd)

Molecular Weight

327.81

Formula

C13H10ClNO3S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=CC([N+]([O-])=O)=C(S1)SCC2=CC=C(C=C2)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (305.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0505 mL 15.2527 mL 30.5055 mL
5 mM 0.6101 mL 3.0505 mL 6.1011 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0505 mL 15.2527 mL 30.5055 mL 76.2637 mL
5 mM 0.6101 mL 3.0505 mL 6.1011 mL 15.2527 mL
10 mM 0.3051 mL 1.5253 mL 3.0505 mL 7.6264 mL
15 mM 0.2034 mL 1.0168 mL 2.0337 mL 5.0842 mL
20 mM 0.1525 mL 0.7626 mL 1.5253 mL 3.8132 mL
25 mM 0.1220 mL 0.6101 mL 1.2202 mL 3.0505 mL
30 mM 0.1017 mL 0.5084 mL 1.0168 mL 2.5421 mL
40 mM 0.0763 mL 0.3813 mL 0.7626 mL 1.9066 mL
50 mM 0.0610 mL 0.3051 mL 0.6101 mL 1.5253 mL
60 mM 0.0508 mL 0.2542 mL 0.5084 mL 1.2711 mL
80 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.9533 mL
100 mM 0.0305 mL 0.1525 mL 0.3051 mL 0.7626 mL
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H111-H7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H111-H7220965-54-8E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseWW domain containing E3 ubiquitin 27 protein ligase 2AKI-to-CKD transitionUIR miceInhibitorinhibitorinhibit

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