2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Mitochondrial Metabolism
  4. Amquinate

Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).

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Amquinate

Amquinate Chemical Structure

CAS No. : 17230-85-2

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Amquinate Related Antibodies

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Description

Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection)[1].

In Vitro

Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC50 of 1×10-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10-4 M[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC50 of 1×10-6 M for succinate-supported respiration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amquinate Related Antibodies
In Vivo

Amquinate (30 ppm; diets) exhibits in vivo anticoccidial activity against wild-type Eimeria tenella in chickens, with a minimal effective dietary dose of 30 ppm[1].
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eimeria tenella[1]
Dosage: 30 ppm
Administration: dietary
Result: Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
Animal Model: Amquinate-resistant Eimeria tenella mutant[1]
Dosage: 2000 ppm
Administration: dietary
Result: Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
Molecular Weight

316.40

Formula

C18H24N2O3
CAS No.
SMILES

O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
Structure Classification
Initial Source

Mitochondria from Eimeria tenella
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Amquinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amquinate17230-85-2ParasiteMitochondrial MetabolismcoccidiosisNADH dehydrogenaseEimeria tenellachicken liver mitochondriamitochondriasuccinate dehydrogenasecoenzyme Qcytochrome banticoccidial activityrespiration inhibitorInhibitorinhibitorinhibit

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