17230-85-2
Chemical Structure
Amquinate
- CAS No.: 17230-85-2
- Formula:C18H24N2O3
- Molecular Weight:316.40
IUPAC Name: methyl 7-(diethylamino)-4-hydroxy-6-propylquinoline-3-carboxylate
InChIKey: NMYCTBARPUAEQN-UHFFFAOYSA-N
SMILES: O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
Biological Activity: Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection)[1].
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Amquinate | Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection). | |||||||||||||||||||||
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