2. Anti-infection
  3. Fungal
  4. SDH-IN-2

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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SDH-IN-2 Chemical Structure

SDH-IN-2 Chemical Structure

CAS No. : 1823354-06-8

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10 mg USD 340 In-stock
25 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

SDH-IN-2 Related Antibodies

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Description

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1]. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) completely inhibits Physalospora piricola infection on apples, and also shows high inhibition rates of 70.9-86.9% on all the fungi even at 20 μg/mL[1].
SDH-IN-2 inhibits P. oryza and F. oxysporum f. sp. niveum with EC50s of 4.33 and 3.56 μg/mL[1].
SDH-IN-2 (0-50 μg/mL) has no effect on the germination rate of bean seeds[1].
SDH-IN-2 (0-100 μg/mL) has no significant effect on the growth of wheat seedlings[1].
SDH-IN-2 inhibits SDH enzymatic activity with an IC50 of 0.55 μg/mL[1].
SDH-IN-2 binds well to the ubiquinone-binding region of SDH by hydrogen bonds and undergoes π–alkyl interaction and π-cation interaction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-2 Related Antibodies
In Vivo

SDH-IN-2 (Compound 13) (0-200 μg/mL, 7 days) inhibits the infection of P. piricola on apples[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

213.16

Formula

C10H6F3NO
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(C(F)(F)F)C=C1)C#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1172.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6913 mL 23.4566 mL 46.9131 mL
5 mM 0.9383 mL 4.6913 mL 9.3826 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6913 mL 23.4566 mL 46.9131 mL 117.2828 mL
5 mM 0.9383 mL 4.6913 mL 9.3826 mL 23.4566 mL
10 mM 0.4691 mL 2.3457 mL 4.6913 mL 11.7283 mL
15 mM 0.3128 mL 1.5638 mL 3.1275 mL 7.8189 mL
20 mM 0.2346 mL 1.1728 mL 2.3457 mL 5.8641 mL
25 mM 0.1877 mL 0.9383 mL 1.8765 mL 4.6913 mL
30 mM 0.1564 mL 0.7819 mL 1.5638 mL 3.9094 mL
40 mM 0.1173 mL 0.5864 mL 1.1728 mL 2.9321 mL
50 mM 0.0938 mL 0.4691 mL 0.9383 mL 2.3457 mL
60 mM 0.0782 mL 0.3909 mL 0.7819 mL 1.9547 mL
80 mM 0.0586 mL 0.2932 mL 0.5864 mL 1.4660 mL
100 mM 0.0469 mL 0.2346 mL 0.4691 mL 1.1728 mL
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SDH-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDH-IN-21823354-06-8FungalAntifungalapplebean seedSDHsuccinate dehydrogenaseInhibitorinhibitorinhibit

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