SDH-IN-2
Based on 1 Customer Validation
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 1823354-06-8
- Formula: C10H6F3NO
- Molecular Weight:213.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library
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Lactic Acid Metabolic Compound Library
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High-Throughput Bioactive Compound Library
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Alkyne Compound Library
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Biological Activity
SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) completely inhibits Physalospora piricola infection on apples, and also shows high inhibition rates of 70.9-86.9% on all the fungi even at 20 μg/mL[1].
SDH-IN-2 inhibits P. oryza and F. oxysporum f. sp. niveum with EC50s of 4.33 and 3.56 μg/mL[1].
SDH-IN-2 (0-50 μg/mL) has no effect on the germination rate of bean seeds[1].
SDH-IN-2 (0-100 μg/mL) has no significant effect on the growth of wheat seedlings[1].
SDH-IN-2 inhibits SDH enzymatic activity with an IC50 of 0.55 μg/mL[1].
SDH-IN-2 binds well to the ubiquinone-binding region of SDH by hydrogen bonds and undergoes π–alkyl interaction and π-cation interaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1823354-06-8
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Appearance Solid
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Molecular Weight 213.16
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Formula C10H6F3NO
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=C(C(F)(F)F)C=C1)C#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (1172.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6913 mL | 23.4566 mL | 46.9131 mL | 117.2828 mL |
| 5 mM | 0.9383 mL | 4.6913 mL | 9.3826 mL | 23.4566 mL | |
| 10 mM | 0.4691 mL | 2.3457 mL | 4.6913 mL | 11.7283 mL | |
| 15 mM | 0.3128 mL | 1.5638 mL | 3.1275 mL | 7.8189 mL | |
| 20 mM | 0.2346 mL | 1.1728 mL | 2.3457 mL | 5.8641 mL | |
| 25 mM | 0.1877 mL | 0.9383 mL | 1.8765 mL | 4.6913 mL | |
| 30 mM | 0.1564 mL | 0.7819 mL | 1.5638 mL | 3.9094 mL | |
| 40 mM | 0.1173 mL | 0.5864 mL | 1.1728 mL | 2.9321 mL | |
| 50 mM | 0.0938 mL | 0.4691 mL | 0.9383 mL | 2.3457 mL | |
| 60 mM | 0.0782 mL | 0.3909 mL | 0.7819 mL | 1.9547 mL | |
| 80 mM | 0.0586 mL | 0.2932 mL | 0.5864 mL | 1.4660 mL | |
| 100 mM | 0.0469 mL | 0.2346 mL | 0.4691 mL | 1.1728 mL |
SDH-IN-2 Related Classifications
HY-148921 Related Classifications
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