2. Anti-infection
  3. Fungal
  4. SDH-IN-1

SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L).

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SDH-IN-1 Chemical Structure

SDH-IN-1 Chemical Structure

CAS No. : 2685795-52-0

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SDH-IN-1 Related Antibodies

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Description

SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L)[1].

Molecular Weight

354.21

Formula

C14H9Cl2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN=C(C2=CC=CS2)O1)NCC3=CC=C(Cl)C(Cl)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (47.06 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8232 mL 14.1159 mL 28.2318 mL
5 mM 0.5646 mL 2.8232 mL 5.6464 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (248 KB) HNMR (247 KB) RP-HPLC (216 KB) MS (127 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8232 mL 14.1159 mL 28.2318 mL 70.5796 mL
5 mM 0.5646 mL 2.8232 mL 5.6464 mL 14.1159 mL
10 mM 0.2823 mL 1.4116 mL 2.8232 mL 7.0580 mL
15 mM 0.1882 mL 0.9411 mL 1.8821 mL 4.7053 mL
20 mM 0.1412 mL 0.7058 mL 1.4116 mL 3.5290 mL
25 mM 0.1129 mL 0.5646 mL 1.1293 mL 2.8232 mL
30 mM 0.0941 mL 0.4705 mL 0.9411 mL 2.3527 mL
40 mM 0.0706 mL 0.3529 mL 0.7058 mL 1.7645 mL
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SDH-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDH-IN-12685795-52-0Fungalsuccinate dehydrogenase?inhibitorantifungal activitiesInhibitorinhibitorinhibit

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