2. Others Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase
  4. Boscalid-d4

Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis.

For research use only. We do not sell to patients.

Boscalid-d<sub>4</sub>

Boscalid-d4 Chemical Structure

CAS No. : 2468796-76-9

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Other Forms of Boscalid-d4:

Boscalid-d4 Related Antibodies

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Description

Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boscalid-d4 Related Antibodies
Molecular Weight

347.23

Formula

C18H8D4Cl2N2O
CAS No.
Unlabeled CAS
Appearance

Solid

SMILES

O=C(C1=CC=CN=C1Cl)NC2=CC=CC=C2C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (287.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8799 mL 14.3997 mL 28.7994 mL
5 mM 0.5760 mL 2.8799 mL 5.7599 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8799 mL 14.3997 mL 28.7994 mL 71.9984 mL
5 mM 0.5760 mL 2.8799 mL 5.7599 mL 14.3997 mL
10 mM 0.2880 mL 1.4400 mL 2.8799 mL 7.1998 mL
15 mM 0.1920 mL 0.9600 mL 1.9200 mL 4.7999 mL
20 mM 0.1440 mL 0.7200 mL 1.4400 mL 3.5999 mL
25 mM 0.1152 mL 0.5760 mL 1.1520 mL 2.8799 mL
30 mM 0.0960 mL 0.4800 mL 0.9600 mL 2.3999 mL
40 mM 0.0720 mL 0.3600 mL 0.7200 mL 1.8000 mL
50 mM 0.0576 mL 0.2880 mL 0.5760 mL 1.4400 mL
60 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.2000 mL
80 mM 0.0360 mL 0.1800 mL 0.3600 mL 0.9000 mL
100 mM 0.0288 mL 0.1440 mL 0.2880 mL 0.7200 mL
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Boscalid-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boscalid-d42468796-76-9Isotope-Labeled CompoundsApoptosisFungalMitochondrial MetabolismSuccinate DehydrogenaseInhibitorinhibitorinhibit

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