Boscalid-d4
Based on 1 Customer Validation
Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2468796-76-9
- Formula: C18H8D4Cl2N2O
- Molecular Weight:347.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2468796-76-9
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Unlabeled Cas 188425-85-6
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Appearance Solid
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Molecular Weight 347.23
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Formula C18H8D4Cl2N2O
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SMILES
O=C(C1=CC=CN=C1Cl)NC2=CC=CC=C2C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (287.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Moschopoulou G, et al. Development of a Portable Cell-Based Biosensor for the Ultra-Rapid Screening for Boscalid Residues in Lettuce. Biosensors (Basel). 2024;14(6):311. Published 2024 Jun 18. [Content Brief]
[3]. Wang H, et al. Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos. Chemosphere. 2020;238:124753. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8799 mL | 14.3997 mL | 28.7994 mL | 71.9984 mL |
| 5 mM | 0.5760 mL | 2.8799 mL | 5.7599 mL | 14.3997 mL | |
| 10 mM | 0.2880 mL | 1.4400 mL | 2.8799 mL | 7.1998 mL | |
| 15 mM | 0.1920 mL | 0.9600 mL | 1.9200 mL | 4.7999 mL | |
| 20 mM | 0.1440 mL | 0.7200 mL | 1.4400 mL | 3.5999 mL | |
| 25 mM | 0.1152 mL | 0.5760 mL | 1.1520 mL | 2.8799 mL | |
| 30 mM | 0.0960 mL | 0.4800 mL | 0.9600 mL | 2.3999 mL | |
| 40 mM | 0.0720 mL | 0.3600 mL | 0.7200 mL | 1.8000 mL | |
| 50 mM | 0.0576 mL | 0.2880 mL | 0.5760 mL | 1.4400 mL | |
| 60 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.2000 mL | |
| 80 mM | 0.0360 mL | 0.1800 mL | 0.3600 mL | 0.9000 mL | |
| 100 mM | 0.0288 mL | 0.1440 mL | 0.2880 mL | 0.7200 mL |
Boscalid-d4 Related Classifications
HY-119976S Related Classifications
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