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antihypertensive+agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Adenylate Cyclase (1) Adrenergic Receptor (39) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (10) Apoptosis (7) Asialoglycoprotein Receptor (ASGPR) (1) Autophagy (13) Bacterial (3) Bradykinin Receptor (1) Calcium Channel (11) Carbonic Anhydrase (2) Cholinesterase (ChE) (1) Drug Derivative (7) Drug Metabolite (12) Endogenous Metabolite (8) Endothelin Receptor (2) HIF/HIF Prolyl-Hydroxylase (1) Imidazoline Receptor (8) Isotope-Labeled Compounds (13) MAPKAPK2 (MK2) (1) NF-κB (2) NKCC (1) NO Synthase (2) Nucleoside Antimetabolite/Analog (57) Phosphoramidites (4) Potassium Channel (12) PTHR (1) Reference Standards (26) Renin (1) Small Interfering RNA (siRNA) (1) TRP Channel (1)
By Research Areas:	Cancer (52) Cardiovascular Disease (94) Endocrinology (9) Infection (3) Inflammation/Immunology (9) Metabolic Disease (13) Neurological Disease (12)
Click Chemistry:	Azide (4) Alkynes (2)
Oligonucleotides:	Nucleoside Analogs (52) Uridine (51) siRNA drugs (1) Uracil (4) Phosphoramidites (4) siRNAs (1)

169

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0112

Minoxidil 10+ Cited Publications U10858	Potassium Channel Endogenous Metabolite	Cardiovascular Disease Cancer
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-B0409A

Clonidine hydrochloride 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

HY-B0566

Guanabenz Acetate 2 Publications Verification BR-750; Wy8678 acetate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.

HY-B0800

Guanethidine sulfate 3 Publications Verification Guanethidine monosulfate	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier .

HY-B0573A

(S)-(-)-Propranolol hydrochloride 2 Publications Verification	Adrenergic Receptor	Cardiovascular Disease
(S)-(-)-Propranolol hydrochloride is a chiral antihypertensive agent with approximately 100-fold higher potency than its R-enantiomer. (S)-(-)-Propranolol hydrochloride can be used for studies on hypertension, angina pectoris and arrhythmia .

HY-15895

Aprocitentan 3 Publications Verification ACT-132577	Endothelin Receptor	Cardiovascular Disease Endocrinology
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC₅₀s of 3.4 nM and 987 nM, and pA₂ valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-107339

Deserpidine Harmonyl	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease Metabolic Disease
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .

HY-B0006A

Carvedilol phosphate hemihydrate 10+ Cited Publications BM 14190 phosphate hemihydrate	Adrenergic Receptor Autophagy Bacterial	Cardiovascular Disease Inflammation/Immunology Cancer
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker . Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC₅₀ of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-N7065

Dihydralazine sulfate	Potassium Channel	Cardiovascular Disease
Dihydralazine sulfate is a vasodilator and an antihypertensive agent .

HY-152899

Selachyl alcohol	Endogenous Metabolite	Cardiovascular Disease
Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research .

HY-12760

Indoramin Indoramine; Wy 21901	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α_1A-adrenoceptor .

HY-152358

N3-Methyl-2’-O-methyluridine	Nucleoside Antimetabolite/Analog	Others
N3-Methyl-2’-O-methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-134337

5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite	Nucleoside Antimetabolite/Analog Phosphoramidites	Cancer
5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-106570

Tripamide	Potassium Channel	Metabolic Disease
Tripamide is an orally active sulfonamide-derived diuretic *antihypertensive agent* .

HY-N7800

Himbacine (+)-Himbacine	Others	Cardiovascular Disease
Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate .

HY-106447

Losulazine	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
Losulazine is an antihypertensive agent acting by a sympatholytic mechanism. Losulazine's hypotensive activity depends on the presence of an intact, functional sympathetic nervous system .

HY-152732

6-Methyluridine	Nucleoside Antimetabolite/Analog	Others
6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-B0409S

Clonidine-d4	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent .

HY-154285

3’-O-(2-Methoxyethyl) uridine	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-B0562

Methyclothiazide	Carbonic Anhydrase	Cardiovascular Disease Metabolic Disease
Methyclothiazide is an orally active *antihypertensive* agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro .

HY-154466

5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-48973

2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite	Nucleoside Antimetabolite/Analog Phosphoramidites	Others
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-154358

4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl) uridine	Nucleoside Antimetabolite/Analog	Cancer
4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-154492

2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-didehydro-5’-deoxyuridine	Nucleoside Antimetabolite/Analog	Cancer
2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-didehydro-5’-deoxyuridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-155041

Antihypertensive agent 2	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 2 (Compound 4g) is an antihypertensive agent. Antihypertensive agent 2 has effective antagonistic activities against angiotensin II receptor 1. Antihypertensive agent 2 reduces the blood pressure with equal or more potency compared to Losartan (HY-17512) .

HY-155042

Antihypertensive agent 3	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model .

HY-101554

Guancydine Guancidine	Adrenergic Receptor	Cardiovascular Disease
Guancydine (Guancidine) is an antihypertensive agent .

HY-100151

RGH-5526 GYKI-11679	Others	Cardiovascular Disease
RGH-5526 (GYKI-11679) is a new antihypertensive agent.

HY-106538

Cadralazine ISF 2469	Drug Derivative	Cardiovascular Disease
Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator .

HY-W700616

Cicletanine hydrochloride	NO Synthase Drug Derivative	Cardiovascular Disease
Cicletanine hydrochloride is an orally active Furopyridine-derivative antihypertensive agent. Cicletanine hydrochloride stimulates NO release. Cicletanine hydrochloride induces effective pulmonary vasodilation .

HY-W726640

Peraquinsin	MAPKAPK2 (MK2)	Cardiovascular Disease Metabolic Disease
Peraquinsin is a MK2 activator. Peraquinsin can be used for the research of vascular disorder or endothelial barrier disorder. Peraquinsin also is an antihypertensive agent .

HY-U00301

Anti-hypertensive sulfonanilide 1	Drug Derivative	Cardiovascular Disease
Anti-hypertensive sulfonanilide 1 is a potent antihypertensive agent extracted from patent EP0338793A2, compound XVIIIa,b*, example No.1.

HY-W020098

2'-C-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-137769

Captopril EP Impurity C 3-Mercaptoisobutyric acid	Drug Metabolite	Others
Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) .

HY-137772

Captopril EP Impurity E	Drug Metabolite	Others
Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) .

HY-154488

3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-U00182

DU717	Endogenous Metabolite	Cardiovascular Disease
DU-717 is an antihypertensive agent.

HY-105718

Olmidine DL-Olmidine	Adrenergic Receptor	Cardiovascular Disease
Olmidine (DL-Olmidine) is an antihypertensive agent. Olmidine acts through inhibition of the adrenergic transmission .

HY-106499A

Sulfinalol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Sulfinalol hydrochloride is an orally active β-adrenoceptor antagonist with direct vasodilator activity. Sulfinalol hydrochloride is an antihypertensive agent .

HY-123563

Metazosin Kenosin	Adrenergic Receptor	Cardiovascular Disease
Metazosin (Kenosin) is a potent α1 adrenoceptor blocker. Metazosin is an antihypertensive agent lowering blood pressure .

HY-B0612ES

(S)-Lercanidipine-d3 hydrochloride	Calcium Channel Isotope-Labeled Compounds	Cardiovascular Disease
(S)-Lercanidipine-d₃ hydrochloride is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent .

HY-108247

Guanethidine sesquisulfate	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Guanethidine sesquisulfate, an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sesquisulfate enters noradrenergic nerve terminals by the neuronal amine carrier .

HY-B0409AR

Clonidine hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

HY-123376

FR-190997	Bradykinin Receptor	Neurological Disease
FR-190997 is a non-peptide Bradykinin B2 receptor selective agonist, K_i value is 9.8 nM. FR-190997 is also an effective antihypertensive agent .

HY-112074

Tiamenidine HOE 440	Adrenergic Receptor	Cardiovascular Disease
Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research .

HY-W042301R

Xipamide (Standard)	NKCC Reference Standards	Cardiovascular Disease
Xipamide (Standard) is the analytical standard of Xipamide. This product is intended for research and analytical applications. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-152755

4’-Cyanouridine	Nucleoside Antimetabolite/Analog	Others
4’-Cyanouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-B0566R

Guanabenz Acetate (Standard) BR-750 (Standard); Wy8678 acetate (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Guanabenz (Acetate) (Standard) is the analytical standard of Guanabenz (Acetate). This product is intended for research and analytical applications. Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.

HY-12749B

(R)-Midodrine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
(R)-Midodrine hydrochloride is a vasopressor used as an antihypertensive agent for the treatment of symptomatic postural hypotension, exhibiting peripheral alpha(1)-adrenoreceptor agonistic activity that induces venous and arterial vasoconstriction.

HY-152764

4’-α-C-Methyluridine	Nucleoside Antimetabolite/Analog	Others
4’-α-C-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

Cat. No.	Product Name	Target	Research Area

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide 1 Publications Verification	Adenylate Cyclase PTHR	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

HY-P10933

PRO20	Renin	Cardiovascular Disease
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC₅₀ value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0112

Minoxidil 10+ Cited Publications U10858	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Potassium Channel Endogenous Metabolite
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-107339

Deserpidine Harmonyl	Apocynaceae Alkaloids Piperidine Alkaloids Plants Rauwolfia canescens Indole Alkaloids	Angiotensin-converting Enzyme (ACE)
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .

HY-118472

Benazeprilat CGS 14831	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-152899

Selachyl alcohol	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research .

HY-B0112R

Minoxidil (Standard) U10858 (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Endogenous metabolite Source Classification	Reference Standards Potassium Channel Endogenous Metabolite
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

HY-N7800

Himbacine (+)-Himbacine	Alkaloids other families Galbulimima baccata Quinoline Alkaloids Plants Source Classification	Others
Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate .

HY-107339R

Deserpidine (Standard) Harmonyl (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Plants Rauwolfia canescens Indole Alkaloids	Reference Standards Angiotensin-converting Enzyme (ACE)
Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .

HY-118472R

Benazeprilat (Standard) CGS 14831 (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-N3103R

p-Coumaric Acid Ethyl Ester (Standard) Ethyl (E)-p-hydroxycinnamate (Standard); Ethyl trans-4-hydroxycinnamate (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Source Classification	Reference Standards Drug Metabolite
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

Cat. No.	Product Name	Chemical Structure

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-23196S

Minoxidil-d10
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

HY-B0006S1

Carvedilol-d4
Carvedilol-d₄ is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-B0409S

Clonidine-d4
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent .

HY-107322S

Barnidipine-d5 hydrochloride

Barnidipine-d₅ (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors .Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

HY-107322AS1

Barnidipine-d5

Barnidipine-d₅ is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d₅ (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i=0.21 nmol/l), has selective action against CaA receptors . Barnidipine-d₅ (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

HY-B0612ES

(S)-Lercanidipine-d3 hydrochloride
(S)-Lercanidipine-d₃ hydrochloride is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent .

HY-W767936

Moxonidine-13C,d3
Moxonidine- ¹³C,d₃ (BDF5895- ¹³C,d₃) is the ¹³C-labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-B0006S

Carvedilol-d3
Carvedilol-d₃ is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-B0006S2

Carvedilol-d5
Carvedilol-d₅ is deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-B0368S

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W653969

Arotinolol-d5 hydrochloride

Arotinolol-d₅ (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker . Arotinolol also shows potency for inhibiting the binding of the radioligand ¹²⁵I-ICYP to 5HT_1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

HY-B0368S1

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W042301S

Xipamide-d6
Xipamide-d₆ is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

Cat. No.	Product Name		Classification

HY-152782

4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine		Azide
4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152476

3’-β-C-Ethynyluridine		Alkynes
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154736

N3-(Butyn-3-yl)uridine		Alkynes
N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152985

3’-Azido-3’-deoxy-4-deoxyuridine		Azide
6-Chloro-N1-(trimethylsilylethoxymethyl)pseudouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-Azido-3’-deoxy-4-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154590

2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine		Azide
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154357

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine		Azide
4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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