2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Pinacidil monohydrate

Pinacidil monohydrate  (Synonyms: P-1134 monohydrate)

Cat. No.: HY-14290A Purity: 99.85%
COA Handling Instructions

Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

For research use only. We do not sell to patients.

Pinacidil monohydrate Chemical Structure

Pinacidil monohydrate Chemical Structure

CAS No. : 85371-64-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 200 In-stock
100 mg USD 300 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Pinacidil monohydrate:

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

In Vitro

Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

263.34

Appearance

Solid

Formula

C13H21N5O
CAS No.
SMILES

[H]O[H].CC(C)(C)C(N/C(NC#N)=N/C1=CC=NC=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (379.74 mM; Need ultrasonic)

Ethanol : 50 mg/mL (189.87 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7974 mL 18.9869 mL 37.9737 mL
5 mM 0.7595 mL 3.7974 mL 7.5947 mL
10 mM 0.3797 mL 1.8987 mL 3.7974 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

  • 6.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.85%

COA (252 KB) HNMR (383 KB) RP-HPLC (207 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pinacidil85371-64-8P-1134P1134P 1134Potassium ChannelKcsAInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pinacidil monohydrate
Cat. No.:
HY-14290A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email address *

Phone number

 

Department *

Organization name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.