2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BNTX

BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ1 opioid receptors, and does not alter the antinociceptive effects mediated by δ2, μ or κ opioid receptors at selective doses.

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BNTX

BNTX Chemical Structure

CAS No. : 129468-28-6

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BNTX Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ1 opioid receptors, and does not alter the antinociceptive effects mediated by δ2, μ or κ opioid receptors at selective doses[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

 

In Vitro

BNTX is highly selective for δ1 opioid receptors in guinea pig brain membranes, with 100-fold greater affinity for δ1 versus δ2 sites[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BNTX Related Antibodies
In Vivo

BNTX (1.3 μmol/kg; subcutaneous injection; single administration; 1 pmole per mouse; intrathecal injection; single administration) acts as a highly selective δ1 opioid receptor antagonist in the mouse spinal cord, and significantly increases the antinociceptive ED50 of the δ1 receptor agonist DPDPE (HY-P1334)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ND4 Swiss-Webster (male, 20-25 g)[1]
Dosage: 1.3 μmol/kg (s.c. pretreatment); 1 pmole/mouse (i.t. pretreatment)
Administration: s.c.; single dose, 30 minutes prior to agonist assay; i.t.; single dose, 10 minutes prior to agonist assay
Result: Increased the antinociceptive ED50 of δ1 agonist DPDPE (i.t.) from 6.3 to 36.1 nmol/mouse at 1.3 μmol/kg s.c. dose.
Did not significantly alter the antinociceptive ED50 of δ2 agonist DELT II (i.t.), μ agonists DAMGO and morphine (i.t.), or κ agonist U-50,488H (i.t.), at 1.3 μmol/kg s.c. dose.
Increased the antinociceptive ED50 of DPDPE (i.t.) from 6.3 to 25.5 nmol/mouse at 1 pmole/mouse i.t. dose.
Did not significantly alter the antinociceptive ED50 of DELT II (i.t.), μ agonist DAMGO (i.t.), or κ agonist U-50,488H (i.t.), at 1 pmole/mouse i.t. dose.
Molecular Weight

429.51

Formula

C27H27NO4
CAS No.
SMILES

O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(/C(C1)=C\C7=CC=CC=C7)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BNTX Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BNTX129468-28-67-BenzylidenenaltrexoneOpioid Receptorantinociceptionguinea pig brain membranesκ opioid receptormiceDPDPEantinociceptive activityopioid receptorInhibitorinhibitorinhibit

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