Guanethidine sesquisulfate
Guanethidine sesquisulfate, an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sesquisulfate enters noradrenergic nerve terminals by the neuronal amine carrier.
For research use only. We do not sell to patients.
- CAS No.: 60-02-6
- Formula: C10H22N4.1/2H2O4S
- Molecular Weight:247.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (approximately 200 g)[2]
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Dosage:5 mg/kg or 40 mg/kg
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Administration:Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
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Result:Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
Chemical Information
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CAS No. 60-02-6
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Molecular Weight 247.34
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Formula C10H22N4.1/2H2O4S
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SMILES
O=S(O)(O)=O.N=C(NCCN1CCCCCCC1)N.[0.5]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6. [Content Brief]
[2]. Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):203-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Guanethidine sesquisulfate Related Classifications
HY-108247 Related Classifications
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