1. Guanethidine

Guanethidine 

Cat. No.: HY-B1251
Handling Instructions

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure
by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

For research use only. We do not sell to patients.

Guanethidine Chemical Structure

Guanethidine Chemical Structure

CAS No. : 55-65-2

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Description

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure
by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

In Vitro

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro[1].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker[2].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) Balb/c,TNFR1(-/-)and IFN(-/-) mice[2].
Dosage: 30 mg/kg
Administration: Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result: Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
Molecular Weight

198.31

Formula

C10H22N4

CAS No.
SMILES

NC(NCCN1CCCCCCC1)=N

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Guanethidine
Cat. No.:
HY-B1251
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