2. Guanethidine

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

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Guanethidine Chemical Structure

Guanethidine Chemical Structure

CAS No. : 55-65-2

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Guanethidine Related Antibodies

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Description

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

In Vitro

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro[1].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanethidine Related Antibodies
In Vivo

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice[2].
Dosage: 30 mg/kg
Administration: Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result: Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
Molecular Weight

198.31

Formula

C10H22N4
CAS No.
SMILES

NC(NCCN1CCCCCCC1)=N
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Purity & Documentation
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Keywords:

Guanethidine55-65-2Inhibitorinhibitorinhibit

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HY-B1251
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