1. Others
  2. Others
  3. Guanethidine sulfate

Guanethidine sulfate  (Synonyms: Guanethidine monosulfate)

Cat. No.: HY-B0800 Purity: ≥98.0%
COA Handling Instructions

Guanethidine sulfate (Guanethidine monosulfate) ia an antihypertensive agents. Guanethidine is also an adrenergic neurone blocking agent, enters noradrenergic nerve terminals by the neuronal amine carrier.

For research use only. We do not sell to patients.

Guanethidine sulfate Chemical Structure

Guanethidine sulfate Chemical Structure

CAS No. : 645-43-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 66 In-stock
Solid
100 mg USD 60 In-stock
500 mg USD 132 In-stock
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Guanethidine sulfate:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Guanethidine sulfate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Guanethidine sulfate (Guanethidine monosulfate) ia an antihypertensive agents. Guanethidine is also an adrenergic neurone blocking agent, enters noradrenergic nerve terminals by the neuronal amine carrier[1][2].

In Vivo

Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (approximately 200 g)[3]
Dosage: 5 mg/kg or 40 mg/kg
Administration: Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
Result: Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
Molecular Weight

296.39

Formula

C10H24N4O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NCCN1CCCCCCC1)=N.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (337.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3739 mL 16.8697 mL 33.7393 mL
5 mM 0.6748 mL 3.3739 mL 6.7479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (337.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.3739 mL 16.8697 mL 33.7393 mL 84.3483 mL
5 mM 0.6748 mL 3.3739 mL 6.7479 mL 16.8697 mL
10 mM 0.3374 mL 1.6870 mL 3.3739 mL 8.4348 mL
15 mM 0.2249 mL 1.1246 mL 2.2493 mL 5.6232 mL
20 mM 0.1687 mL 0.8435 mL 1.6870 mL 4.2174 mL
25 mM 0.1350 mL 0.6748 mL 1.3496 mL 3.3739 mL
30 mM 0.1125 mL 0.5623 mL 1.1246 mL 2.8116 mL
40 mM 0.0843 mL 0.4217 mL 0.8435 mL 2.1087 mL
50 mM 0.0675 mL 0.3374 mL 0.6748 mL 1.6870 mL
60 mM 0.0562 mL 0.2812 mL 0.5623 mL 1.4058 mL
80 mM 0.0422 mL 0.2109 mL 0.4217 mL 1.0544 mL
100 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.8435 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Guanethidine sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Guanethidine sulfate
Cat. No.:
HY-B0800
Quantity:
MCE Japan Authorized Agent: