Guanethidine sulfate
Based on 3 publication(s) in Google Scholar
Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 645-43-2
- Formula: C10H24N4O4S
- Molecular Weight:296.39
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Guanethidine sulfate
MoreAll Adrenergic Receptor Isoforms
More
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (approximately 200 g)[3]
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Dosage:5 mg/kg or 40 mg/kg
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Administration:Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
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Result:Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
Chemical Information
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CAS No. 645-43-2
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Appearance Solid
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Molecular Weight 296.39
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Formula C10H24N4O4S
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Color White to off-white
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SMILES
NC(NCCN1CCCCCCC1)=N.O=S(O)(O)=O
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Synonyms
Guanethidine monosulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. [Abstract]2025 Jun 5;16(1):5215. PMID: 40473608 -
iScience
2026 Feb 23;29(3):115122. PMID: 41852725 -
Solvent & Solubility
H2O : 100 mg/mL (337.39 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (337.39 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6. [Content Brief]
[2]. Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):203-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3739 mL | 16.8697 mL | 33.7393 mL | 84.3483 mL |
| 5 mM | 0.6748 mL | 3.3739 mL | 6.7479 mL | 16.8697 mL | |
| 10 mM | 0.3374 mL | 1.6870 mL | 3.3739 mL | 8.4348 mL | |
| 15 mM | 0.2249 mL | 1.1246 mL | 2.2493 mL | 5.6232 mL | |
| 20 mM | 0.1687 mL | 0.8435 mL | 1.6870 mL | 4.2174 mL | |
| 25 mM | 0.1350 mL | 0.6748 mL | 1.3496 mL | 3.3739 mL | |
| 30 mM | 0.1125 mL | 0.5623 mL | 1.1246 mL | 2.8116 mL | |
| 40 mM | 0.0843 mL | 0.4217 mL | 0.8435 mL | 2.1087 mL | |
| 50 mM | 0.0675 mL | 0.3374 mL | 0.6748 mL | 1.6870 mL | |
| 60 mM | 0.0562 mL | 0.2812 mL | 0.5623 mL | 1.4058 mL | |
| 80 mM | 0.0422 mL | 0.2109 mL | 0.4217 mL | 1.0544 mL | |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8435 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanethidine sulfate Related Classifications
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