Dihydralazine sulfate
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Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 7327-87-9
- Formula: C8H12N6O4S
- Molecular Weight:288.28
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Dihydralazine sulfate (1 mg per plate, up to 14 μmol; standard Ames test incubation period) acts as a low-potency direct-acting mutagen in Salmonella typhimurium strains TA100, TA97, TA1537, TA98, and TA1538[1].
Dihydralazine sulfate (5 mg (17.4 μmol) per spot; 24 h) is preferentially lethal to DNA repair-deficient Escherichia coli strains CM871 and TM1080, but not to excision repair-deficient WP2uvrA, indicating it induces DNA damage repaired primarily by recA recombination and lexA post-replication repair pathways[1].
Dihydralazine sulfate exhibits preferential lethality to DNA repair-deficient Escherichia coli strains WP67 and CM871, with MIC values of 12.5 μg for both strains without S-9 mix[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Dihydralazine sulfate (0.1-2 mg/kg; intravenous injection; single dose) inhibited hemorrhagic hypotension in rats with renal hypertension (RHR) and spontaneous hypertension (SHR) without a decrease in cerebral blood flow (CBF)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Noninbred male Swiss mice (2-3 months old)[1]
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Dosage:53 mg/kg (daily x5)
79.5 mg/kg; 159 mg/kg; 318 mg/kg (single dose) -
Administration:i.p.; single dose; daily for 5 successive days
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Result:Found no hepatic DNA damage across all tested doses and timepoints.
Elevated lung DNA elution rate at 6 h and 12 h (159 mg/kg single dose), 4 h (318 mg/kg single dose), and 6 h post five daily 53 mg/kg doses.
Elevated kidney DNA elution rate at 12 h after single 159 mg/kg administration.
Elevated spleen DNA elution rate at 6 h and 12 h (159 mg/kg single dose), and 6 h after five daily 53 mg/kg doses.
Boosted SCEs per diploid bone marrow cell by 58% following single 79.5 mg/kg dosing.
Chemical Information
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CAS No. 7327-87-9
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Appearance Solid
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Molecular Weight 288.28
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Formula C8H12N6O4S
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Color Off-white to light yellow
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SMILES
N/N=C(C1=C/2C=CC=C1)\NNC2=N/N.O=S(O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 4.17 mg/mL (14.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. de Flora S, et al. In vivo and in vitro genotoxicity of three antihypertensive hydrazine derivatives (hydralazine, dihydralazine, and endralazine). Environ Mutagen. 1982;4(5):605-19. [Content Brief]
[2]. Bolte AC, et al. Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome. Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):371-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4688 mL | 17.3442 mL | 34.6885 mL | 86.7212 mL |
| 5 mM | 0.6938 mL | 3.4688 mL | 6.9377 mL | 17.3442 mL | |
| 10 mM | 0.3469 mL | 1.7344 mL | 3.4688 mL | 8.6721 mL |
Dihydralazine sulfate Related Classifications
HY-N7065 Related Classifications
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