4'-C-Azidouridine
4'-C-azidouridine (4'-Azidouridine) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. 4'-C-Azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- CAS No.: 139442-01-6
- Formula: C9H11N5O6
- Molecular Weight:285.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
73 μM
Compound: 6b
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Compound was tested in vitro for inhibition of cytopathogenicity of LAV(IIIB) in CD4+ T-cells (A3.01)
Compound was tested in vitro for inhibition of cytopathogenicity of LAV(IIIB) in CD4+ T-cells (A3.01)
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[PMID: 1573638] |
Chemical Information
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CAS No. 139442-01-6
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Appearance Solid
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Molecular Weight 285.21
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Formula C9H11N5O6
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Color White to off-white
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SMILES
O[C@@H]1[C@H](O)[C@](CO)(N=[N+]=[N-])O[C@H]1N2C(NC(C=C2)=O)=O
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Synonyms
4'-Azidouridine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (350.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5062 mL | 17.5309 mL | 35.0619 mL | 87.6547 mL |
| 5 mM | 0.7012 mL | 3.5062 mL | 7.0124 mL | 17.5309 mL | |
| 10 mM | 0.3506 mL | 1.7531 mL | 3.5062 mL | 8.7655 mL | |
| 15 mM | 0.2337 mL | 1.1687 mL | 2.3375 mL | 5.8436 mL | |
| 20 mM | 0.1753 mL | 0.8765 mL | 1.7531 mL | 4.3827 mL | |
| 25 mM | 0.1402 mL | 0.7012 mL | 1.4025 mL | 3.5062 mL | |
| 30 mM | 0.1169 mL | 0.5844 mL | 1.1687 mL | 2.9218 mL | |
| 40 mM | 0.0877 mL | 0.4383 mL | 0.8765 mL | 2.1914 mL | |
| 50 mM | 0.0701 mL | 0.3506 mL | 0.7012 mL | 1.7531 mL | |
| 60 mM | 0.0584 mL | 0.2922 mL | 0.5844 mL | 1.4609 mL | |
| 80 mM | 0.0438 mL | 0.2191 mL | 0.4383 mL | 1.0957 mL | |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8765 mL |
4'-C-Azidouridine Related Classifications
HY-77650 Related Classifications
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