Arotinolol-d5 hydrochloride
Arotinolol-d5 (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 2514848-16-7
- Formula: C15H17D5ClN3O2S3
- Molecular Weight:413.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT1B Receptor |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2514848-16-7
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Unlabeled Cas 68377-92-4
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Molecular Weight 413.03
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Formula C15H17D5ClN3O2S3
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SMILES
O=C(C1=CC=C(S1)C2=CSC(SC([2H])(C([2H])(C([2H])(NC(C)(C)C)[2H])O)[2H])=N2)N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 125 mg/mL (302.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats.PLoS One. 2014 Feb 12;9(2):e88722. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4211 mL | 12.1057 mL | 24.2113 mL | 60.5283 mL |
| 5 mM | 0.4842 mL | 2.4211 mL | 4.8423 mL | 12.1057 mL | |
| 10 mM | 0.2421 mL | 1.2106 mL | 2.4211 mL | 6.0528 mL | |
| 15 mM | 0.1614 mL | 0.8070 mL | 1.6141 mL | 4.0352 mL | |
| 20 mM | 0.1211 mL | 0.6053 mL | 1.2106 mL | 3.0264 mL | |
| 25 mM | 0.0968 mL | 0.4842 mL | 0.9685 mL | 2.4211 mL | |
| 30 mM | 0.0807 mL | 0.4035 mL | 0.8070 mL | 2.0176 mL | |
| 40 mM | 0.0605 mL | 0.3026 mL | 0.6053 mL | 1.5132 mL | |
| 50 mM | 0.0484 mL | 0.2421 mL | 0.4842 mL | 1.2106 mL | |
| 60 mM | 0.0404 mL | 0.2018 mL | 0.4035 mL | 1.0088 mL | |
| 80 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.7566 mL | |
| 100 mM | 0.0242 mL | 0.1211 mL | 0.2421 mL | 0.6053 mL |
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